Influence of process parameters on nimesulide-loaded Poly(D,L-lactide-co-glycolide) microcapsules

Nimesulide was formulated as sustained release microcapsules using biodegradable polymer Poly(D,L-lactide-co-glycolide) (PLGA) as the release material by non-solvent addition coacervation method. The prepared microcapsules were evaluated for physico-chemical properties i.e. size analysis, morphol...

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Autores principales: Khan, Shujaat A., Ahmad, Mahmood, Murtaza, Ghulam, Aamir, Muhammad N., Rasool, Fatima, Raees, Muhammad A.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Agentes Antiinflamatorios no Esteroides
biodegradable microspheres; microencapsulation; nimesulide; PLGA
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8110
http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_1_18.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8110
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Agentes Antiinflamatorios no Esteroides
biodegradable microspheres; microencapsulation; nimesulide; PLGA
spellingShingle Farmacia
Agentes Antiinflamatorios no Esteroides
biodegradable microspheres; microencapsulation; nimesulide; PLGA
Khan, Shujaat A.
Ahmad, Mahmood
Murtaza, Ghulam
Aamir, Muhammad N.
Rasool, Fatima
Raees, Muhammad A.
Influence of process parameters on nimesulide-loaded Poly(D,L-lactide-co-glycolide) microcapsules
topic_facet Farmacia
Agentes Antiinflamatorios no Esteroides
biodegradable microspheres; microencapsulation; nimesulide; PLGA
description Nimesulide was formulated as sustained release microcapsules using biodegradable polymer Poly(D,L-lactide-co-glycolide) (PLGA) as the release material by non-solvent addition coacervation method. The prepared microcapsules were evaluated for physico-chemical properties i.e. size analysis, morphology, micromeritics, drug content, encapsulation efficiency and drug release characteristics. All microcapsules obtained were discrete, large, free flowing and spherical in shape. The maximum encapsulation efficiency of nimesulide was up to 81.02 ± 2.10 %. Nimesulide release from microcapsules followed Higuchi model. Slow release of nimesulide from PLGA microcapsules over 12 h was observed.
format Articulo
Articulo
author Khan, Shujaat A.
Ahmad, Mahmood
Murtaza, Ghulam
Aamir, Muhammad N.
Rasool, Fatima
Raees, Muhammad A.
author_facet Khan, Shujaat A.
Ahmad, Mahmood
Murtaza, Ghulam
Aamir, Muhammad N.
Rasool, Fatima
Raees, Muhammad A.
author_sort Khan, Shujaat A.
title Influence of process parameters on nimesulide-loaded Poly(D,L-lactide-co-glycolide) microcapsules
title_short Influence of process parameters on nimesulide-loaded Poly(D,L-lactide-co-glycolide) microcapsules
title_full Influence of process parameters on nimesulide-loaded Poly(D,L-lactide-co-glycolide) microcapsules
title_fullStr Influence of process parameters on nimesulide-loaded Poly(D,L-lactide-co-glycolide) microcapsules
title_full_unstemmed Influence of process parameters on nimesulide-loaded Poly(D,L-lactide-co-glycolide) microcapsules
title_sort influence of process parameters on nimesulide-loaded poly(d,l-lactide-co-glycolide) microcapsules
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8110
http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_1_18.pdf
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