In vivo genotoxicity evaluation of crude extract from Ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice

Extracts from Ledum palustre (LP) have shown many benefit activities, while, the toxicity of extracts from LP was seldom reported. In the present study, we evaluated the genotoxicity of crude extract from LP. Our results demonstrated that the maximal tolerance dose (MTD) of LP extract was more tha...

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Autores principales: Xuming, Deng, Wenhui, Qian, Xue, Shen, Na, Guo, Jingbo, Liu, Shuang, Guan, Jing, Lu
Formato: Articulo
Lenguaje:Español
Publicado: 2011
Materias:
Farmacia
Extractos Vegetales
acute toxicity; antioxidant activity; chromosome aberration test; Ledum palustre; micronucleus test; sperm morphology test
Genotoxicidad
Ciclofosfamida
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8109
http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_1_17.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8109
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Farmacia
Extractos Vegetales
acute toxicity; antioxidant activity; chromosome aberration test; Ledum palustre; micronucleus test; sperm morphology test
Genotoxicidad
Ciclofosfamida
spellingShingle Farmacia
Extractos Vegetales
acute toxicity; antioxidant activity; chromosome aberration test; Ledum palustre; micronucleus test; sperm morphology test
Genotoxicidad
Ciclofosfamida
Xuming, Deng
Wenhui, Qian
Xue, Shen
Na, Guo
Jingbo, Liu
Shuang, Guan
Jing, Lu
In vivo genotoxicity evaluation of crude extract from Ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice
topic_facet Farmacia
Extractos Vegetales
acute toxicity; antioxidant activity; chromosome aberration test; Ledum palustre; micronucleus test; sperm morphology test
Genotoxicidad
Ciclofosfamida
description Extracts from Ledum palustre (LP) have shown many benefit activities, while, the toxicity of extracts from LP was seldom reported. In the present study, we evaluated the genotoxicity of crude extract from LP. Our results demonstrated that the maximal tolerance dose (MTD) of LP extract was more than 30 g/kg BW in mice (oral). LP extract at doses of 2.5, 5.0 and 10.0 g/kg BW had no genotoxicity in mice and could inhibit cyclophosphamide (CP), a well known anti-tumor drug, induced genotoxicity in mice. LP extract at concentrations of 0.05 g/mL, 0.005 g/mL, and 0.0005 g/ mL had scavenging activity on O2-·in a dose-related way. It was concluded that LP extract had protective effects on CP induced genotoxicity in mice and the protective mechanism of LP extract appeared to be related to antioxidant activity.
format Articulo
Articulo
author Xuming, Deng
Wenhui, Qian
Xue, Shen
Na, Guo
Jingbo, Liu
Shuang, Guan
Jing, Lu
author_facet Xuming, Deng
Wenhui, Qian
Xue, Shen
Na, Guo
Jingbo, Liu
Shuang, Guan
Jing, Lu
author_sort Xuming, Deng
title In vivo genotoxicity evaluation of crude extract from Ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice
title_short In vivo genotoxicity evaluation of crude extract from Ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice
title_full In vivo genotoxicity evaluation of crude extract from Ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice
title_fullStr In vivo genotoxicity evaluation of crude extract from Ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice
title_full_unstemmed In vivo genotoxicity evaluation of crude extract from Ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice
title_sort in vivo genotoxicity evaluation of crude extract from ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8109
http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_1_17.pdf
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