Treatment with Enterococcus faecalis CECT7121 Is Not Effective as Therapy in Mice with an Established Allergy Status

In allergies, an unbalanced immune response towards a T helper (Th) 2 profile with high levels of Immunoglobulin (Ig) E is produced. We have demonstrated that the pre-administration of Enterococcus faecalis CECT7121 prevents the development of allergy in ovalbumin-immunized mice. In this work, we ev...

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Detalles Bibliográficos
Autores principales:	Díaz, Ailén M., Molina, Matías A., Nuñez, Guillermo G., Mourelle, Ana C., Sparo, Mónica Delfina, Manghi, Marcela A., Castro, Marisa, S.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2017
Materias:	Ciencias Médicas Enterococcus faecalis CECT7121 Ovalbumin-Allergy Murine Model Immunoglobulin E Th2 Cytokines Probiotics
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/81082
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas Enterococcus faecalis CECT7121 Ovalbumin-Allergy Murine Model Immunoglobulin E Th2 Cytokines Probiotics
spellingShingle	Ciencias Médicas Enterococcus faecalis CECT7121 Ovalbumin-Allergy Murine Model Immunoglobulin E Th2 Cytokines Probiotics Díaz, Ailén M. Molina, Matías A. Nuñez, Guillermo G. Mourelle, Ana C. Sparo, Mónica Delfina Manghi, Marcela A. Castro, Marisa, S. Treatment with Enterococcus faecalis CECT7121 Is Not Effective as Therapy in Mice with an Established Allergy Status
topic_facet	Ciencias Médicas Enterococcus faecalis CECT7121 Ovalbumin-Allergy Murine Model Immunoglobulin E Th2 Cytokines Probiotics
description	In allergies, an unbalanced immune response towards a T helper (Th) 2 profile with high levels of Immunoglobulin (Ig) E is produced. We have demonstrated that the pre-administration of Enterococcus faecalis CECT7121 prevents the development of allergy in ovalbumin-immunized mice. In this work, we evaluated whether this bacterium can also revert an established allergic status. Mice were immunized with ovalbumin (OVA) and after that, were inoculated with an E. faecalis CECT7121 suspension. In immunized animals, serum specific immune response, proliferative activity of memory splenocytes, and levels of Th2 cytokines were assessed. The in vivo active cutaneous anaphylaxis test was also performed. The treatment with E. faecalis CECT7121 only increased anti-OVA IgG2a levels. No differences were observed in other specific immunological parameters. Probiotic-treatment did not prove to have any desensitizing effect on mice. These results, together with those recently published, can be concluded that this bacterium would not be appropriate for the treatment of allergic symptoms.
format	Articulo Articulo
author	Díaz, Ailén M. Molina, Matías A. Nuñez, Guillermo G. Mourelle, Ana C. Sparo, Mónica Delfina Manghi, Marcela A. Castro, Marisa, S.
author_facet	Díaz, Ailén M. Molina, Matías A. Nuñez, Guillermo G. Mourelle, Ana C. Sparo, Mónica Delfina Manghi, Marcela A. Castro, Marisa, S.
author_sort	Díaz, Ailén M.
title	Treatment with Enterococcus faecalis CECT7121 Is Not Effective as Therapy in Mice with an Established Allergy Status
title_short	Treatment with Enterococcus faecalis CECT7121 Is Not Effective as Therapy in Mice with an Established Allergy Status
title_full	Treatment with Enterococcus faecalis CECT7121 Is Not Effective as Therapy in Mice with an Established Allergy Status
title_fullStr	Treatment with Enterococcus faecalis CECT7121 Is Not Effective as Therapy in Mice with an Established Allergy Status
title_full_unstemmed	Treatment with Enterococcus faecalis CECT7121 Is Not Effective as Therapy in Mice with an Established Allergy Status
title_sort	treatment with enterococcus faecalis cect7121 is not effective as therapy in mice with an established allergy status
publishDate	2017
url	http://sedici.unlp.edu.ar/handle/10915/81082
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Treatment with Enterococcus faecalis CECT7121 Is Not Effective as Therapy in Mice with an Established Allergy Status

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