Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9

The interaction between some chemokines with tumoral and stromal cells can influence tumor progression. CXCL9, a monokine induced by interferon gamma (MIG), targets lymphocytes. The aim of our study was to identify and quantify CD4+ and CD8+ T cells in the stroma of human breast cancer and correlate...

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Autores principales: Laguens, Graciela, Coronato, Silvia, Chambó, Jorge, Di Girolamo, María Teresa Vanda
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Ciencias Médicas
Breast Cancer
CD4+ T cells
CD8+ T Cells’ MIG/CXCL9
Chemokines
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/81072
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-81072
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Breast Cancer
CD4+ T cells
CD8+ T Cells’ MIG/CXCL9
Chemokines
spellingShingle Ciencias Médicas
Breast Cancer
CD4+ T cells
CD8+ T Cells’ MIG/CXCL9
Chemokines
Laguens, Graciela
Coronato, Silvia
Chambó, Jorge
Di Girolamo, María Teresa Vanda
Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9
topic_facet Ciencias Médicas
Breast Cancer
CD4+ T cells
CD8+ T Cells’ MIG/CXCL9
Chemokines
description The interaction between some chemokines with tumoral and stromal cells can influence tumor progression. CXCL9, a monokine induced by interferon gamma (MIG), targets lymphocytes. The aim of our study was to identify and quantify CD4+ and CD8+ T cells in the stroma of human breast cancer and correlate them with the presence of MIG/CXCL9. In 58 specimens of human breast carcinoma and 10 normal breast tissue from mammoplasty surgery, immunohistochemis- try and ELISA methods were performed. The number of CD4+ and CD8+ T cells in breast cancer tissue was signifi-cantly increased compared with normal breast tissue with a clear predominance of CD8+ T cells. MIG/CXCL9 levels were significantly elevated respect normal breast tissue. This chemokine correlated with the number of CD8+ T cells only in non-metastatic tumors. These data suggest that MIG targets cytotoxic T cells. Their recruitment into breast car-cinoma can play a critical role in malignant progression, inhibiting the production of metastasis.
format Articulo
Articulo
author Laguens, Graciela
Coronato, Silvia
Chambó, Jorge
Di Girolamo, María Teresa Vanda
author_facet Laguens, Graciela
Coronato, Silvia
Chambó, Jorge
Di Girolamo, María Teresa Vanda
author_sort Laguens, Graciela
title Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9
title_short Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9
title_full Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9
title_fullStr Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9
title_full_unstemmed Stromal CD4+ and CD8+ T Cells in Human Breast Carcinomas: Its Correlation with Chemokine MIG/CXCL9
title_sort stromal cd4+ and cd8+ t cells in human breast carcinomas: its correlation with chemokine mig/cxcl9
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/81072
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