A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam

A flow-through optosensing system for oxazepam recognition with fluorescence detection was performed by means of a molecular imprinted polymer based on its acid hydrolysis product, 2-amino-5-chlorobenzophenone. )e synthesis was conducted via a noncovalent imprinting methodology, using methacrylic ac...

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Autores principales: Machicote, Roberta Grisel, Castillo, Marcela A., Pacheco, María Emilia, Bruzzone, Liliana
Formato: Articulo
Lenguaje:Inglés
Publicado: 2018
Materias:
Química
benzodiazepines
oxazepam
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/81069
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-81069
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
benzodiazepines
oxazepam
spellingShingle Química
benzodiazepines
oxazepam
Machicote, Roberta Grisel
Castillo, Marcela A.
Pacheco, María Emilia
Bruzzone, Liliana
A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam
topic_facet Química
benzodiazepines
oxazepam
description A flow-through optosensing system for oxazepam recognition with fluorescence detection was performed by means of a molecular imprinted polymer based on its acid hydrolysis product, 2-amino-5-chlorobenzophenone. )e synthesis was conducted via a noncovalent imprinting methodology, using methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent. Hydrolysis (types and concentration of acids), polymer retention capacity, binding properties, and elution (selectivity and reversibility) conditions were optimized. )eselected molecular imprinted polymer had a molar ratio composition of 1 : 6 : 45 (template : functional monomer : cross-linker). )e proposed method was applied to the determination of oxazepam in a pharmaceutical formulation. External standard calibration, standard additions calibration, and Youden’s calibration were carried out in order to evaluate constant and proportional errors due to the matrix. )e developed metabolite-based recognition system for benzodiazepines is an innovative procedure that could be followed in routine and quality control assays.
format Articulo
Articulo
author Machicote, Roberta Grisel
Castillo, Marcela A.
Pacheco, María Emilia
Bruzzone, Liliana
author_facet Machicote, Roberta Grisel
Castillo, Marcela A.
Pacheco, María Emilia
Bruzzone, Liliana
author_sort Machicote, Roberta Grisel
title A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam
title_short A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam
title_full A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam
title_fullStr A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam
title_full_unstemmed A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam
title_sort molecular imprinted polymer as a flow-through optical sensor for oxazepam
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/81069
work_keys_str_mv AT machicoterobertagrisel amolecularimprintedpolymerasaflowthroughopticalsensorforoxazepam
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AT pachecomariaemilia amolecularimprintedpolymerasaflowthroughopticalsensorforoxazepam
AT bruzzoneliliana amolecularimprintedpolymerasaflowthroughopticalsensorforoxazepam
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AT castillomarcelaa molecularimprintedpolymerasaflowthroughopticalsensorforoxazepam
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bdutipo_str Repositorios
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