Docking Applied to the Study of Inhibitors of c-Met Kinase

Quinoxaline derivatives were studied as inhibitors of c-Met kinase, a receptor associated with high tumor grade and poor prognosis in a number of human cancers. In this paper we used docking methodologies to predict the binding conformation of a set of quinoxalines and to explain the differences of...

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Detalles Bibliográficos
Autores principales: Gavernet, Luciana, Palestro, Pablo Hernán, Bruno Blanch, Luis Enrique
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Química
Quinoxaline
c-Met kinase
inhibitors
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/81055
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-81055
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Quinoxaline
c-Met kinase
inhibitors
spellingShingle Química
Quinoxaline
c-Met kinase
inhibitors
Gavernet, Luciana
Palestro, Pablo Hernán
Bruno Blanch, Luis Enrique
Docking Applied to the Study of Inhibitors of c-Met Kinase
topic_facet Química
Quinoxaline
c-Met kinase
inhibitors
description Quinoxaline derivatives were studied as inhibitors of c-Met kinase, a receptor associated with high tumor grade and poor prognosis in a number of human cancers. In this paper we used docking methodologies to predict the binding conformation of a set of quinoxalines and to explain the differences of biological activities previously reported.
format Articulo
Articulo
author Gavernet, Luciana
Palestro, Pablo Hernán
Bruno Blanch, Luis Enrique
author_facet Gavernet, Luciana
Palestro, Pablo Hernán
Bruno Blanch, Luis Enrique
author_sort Gavernet, Luciana
title Docking Applied to the Study of Inhibitors of c-Met Kinase
title_short Docking Applied to the Study of Inhibitors of c-Met Kinase
title_full Docking Applied to the Study of Inhibitors of c-Met Kinase
title_fullStr Docking Applied to the Study of Inhibitors of c-Met Kinase
title_full_unstemmed Docking Applied to the Study of Inhibitors of c-Met Kinase
title_sort docking applied to the study of inhibitors of c-met kinase
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/81055
work_keys_str_mv AT gavernetluciana dockingappliedtothestudyofinhibitorsofcmetkinase
AT palestropablohernan dockingappliedtothestudyofinhibitorsofcmetkinase
AT brunoblanchluisenrique dockingappliedtothestudyofinhibitorsofcmetkinase
bdutipo_str Repositorios
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