Dosage of atenolol tablets by spectrophotometry with phenol red

A spectrophotometric method is proposed for the analysis of atenolol, based on its reaction with the indicator phenol red in an acetone environment. Experimental conditions for the formation of an ion pair complex peaking at 388 nm were optimized. The method is linear in the range of 1 to 5 mg/mL wi...

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Autores principales: Ramírez Maisuls, Hugo Enrique, Monzón, Celina M., Delfino, Mario R., Sarno, María del C.
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
atenolol; ion pair; phenol red; spectrophotometry
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8087
http://www.latamjpharm.org/resumenes/29/8/LAJOP_29_8_2_4.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8087
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
atenolol; ion pair; phenol red; spectrophotometry
spellingShingle Farmacia
atenolol; ion pair; phenol red; spectrophotometry
Ramírez Maisuls, Hugo Enrique
Monzón, Celina M.
Delfino, Mario R.
Sarno, María del C.
Dosage of atenolol tablets by spectrophotometry with phenol red
topic_facet Farmacia
atenolol; ion pair; phenol red; spectrophotometry
description A spectrophotometric method is proposed for the analysis of atenolol, based on its reaction with the indicator phenol red in an acetone environment. Experimental conditions for the formation of an ion pair complex peaking at 388 nm were optimized. The method is linear in the range of 1 to 5 mg/mL with a correlation coefficient (n = 30) of 0.9968. Stoichiometry of the reaction is 1: 1. Free energy change (ΔG) for complex formation and stability constant (K<sub>F</sub>) have been calculated. Working with placebo it was found that excipients do not interfere in the analysis. The proposed method was applied to tablets provided by the Medicinal Plant of Corrientes (Plamecor), Argentina. Recoveries from 99.67 to 100.17 were achieved. Results were compared (F test and t test) favorably with those given by official methods. (HPLC - UV).
format Articulo
Comunicacion
author Ramírez Maisuls, Hugo Enrique
Monzón, Celina M.
Delfino, Mario R.
Sarno, María del C.
author_facet Ramírez Maisuls, Hugo Enrique
Monzón, Celina M.
Delfino, Mario R.
Sarno, María del C.
author_sort Ramírez Maisuls, Hugo Enrique
title Dosage of atenolol tablets by spectrophotometry with phenol red
title_short Dosage of atenolol tablets by spectrophotometry with phenol red
title_full Dosage of atenolol tablets by spectrophotometry with phenol red
title_fullStr Dosage of atenolol tablets by spectrophotometry with phenol red
title_full_unstemmed Dosage of atenolol tablets by spectrophotometry with phenol red
title_sort dosage of atenolol tablets by spectrophotometry with phenol red
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/8087
http://www.latamjpharm.org/resumenes/29/8/LAJOP_29_8_2_4.pdf
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AT sarnomariadelc dosageofatenololtabletsbyspectrophotometrywithphenolred
bdutipo_str Repositorios
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