Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits

Oxidized Low-Density Lipoproteins (oxLDL) and autoantibodies against oxLDL are important in the development of atherosclerotic lesions. Statins are efficacious in the control of dyslipidemia and prevention of atherosclerosis; however, many questions concerning the mechanism of action of such drugs...

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Detalles Bibliográficos
Autores principales: Cavallini, Daniela C. U., Abdalla, Dulcinéia S. P., Pauly-Silveira, Nadiége D., Rossi, Elizeu A.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
atherosclerosis; autoantibodies against oxidized LDL; simvastatin
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8082
http://www.latamjpharm.org/resumenes/29/8/LAJOP_29_8_1_22.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8082
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
atherosclerosis; autoantibodies against oxidized LDL; simvastatin
spellingShingle Farmacia
atherosclerosis; autoantibodies against oxidized LDL; simvastatin
Cavallini, Daniela C. U.
Abdalla, Dulcinéia S. P.
Pauly-Silveira, Nadiége D.
Rossi, Elizeu A.
Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits
topic_facet Farmacia
atherosclerosis; autoantibodies against oxidized LDL; simvastatin
description Oxidized Low-Density Lipoproteins (oxLDL) and autoantibodies against oxLDL are important in the development of atherosclerotic lesions. Statins are efficacious in the control of dyslipidemia and prevention of atherosclerosis; however, many questions concerning the mechanism of action of such drugs remain unknown. This work investigated the effect of simvastatin on generation of autoantibodies against oxLDL and development of atherosclerosis in rabbits. The animals were divided into three groups: control, hypercholesterolemic, and hypercholesterolemic simvastatin (3.0 mg simvastatin/ kg body weight). Concentrations of autoantibodies against oxLDL were determined on days 0, 30 and 60 of the experiment and the atherosclerotic lesions were evaluated at the end of the study. Simvastatin reduced intimal proliferation in the thoracic region, prevented arterial calcification and inhibited the generation of autoantibodies against oxLDL. In conclusion, daily administration of simvastatin slows down atherosclerotic lesion development in rabbits with induced hypercholesterolemia and inhibition on generation of autoantibodies against oxLDL contributes to the cardioprotective effect observed.
format Articulo
Articulo
author Cavallini, Daniela C. U.
Abdalla, Dulcinéia S. P.
Pauly-Silveira, Nadiége D.
Rossi, Elizeu A.
author_facet Cavallini, Daniela C. U.
Abdalla, Dulcinéia S. P.
Pauly-Silveira, Nadiége D.
Rossi, Elizeu A.
author_sort Cavallini, Daniela C. U.
title Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits
title_short Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits
title_full Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits
title_fullStr Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits
title_full_unstemmed Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits
title_sort effect of simvastatin on the generation of autoantibodies against oxidized ldl and progression of atherosclerosis in rabbits
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/8082
http://www.latamjpharm.org/resumenes/29/8/LAJOP_29_8_1_22.pdf
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