In vitro absorption studies of acyclovir using natural permeation enhancers

Gastroretentive Delivery Systems are employed to improve the bioavailability of drugs which are absorbed through upper part of GIT, by increasing their retention time. Incorporation of permeability enhancers in the formulations of such drugs can further increase their bioavailability; however thei...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Dias, Remeth J., Mali, Kailas K., Ghorpade, Vishwajeet S., Garje, Sandeep B., Havaldar, Vijay D.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
acyclovir; aloe vera; chausath prahar pippa; natural permeation enhancer
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8081
http://www.latamjpharm.org/resumenes/29/8/LAJOP_29_8_1_21.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8081
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
acyclovir; aloe vera; chausath prahar pippa; natural permeation enhancer
spellingShingle Farmacia
acyclovir; aloe vera; chausath prahar pippa; natural permeation enhancer
Dias, Remeth J.
Mali, Kailas K.
Ghorpade, Vishwajeet S.
Garje, Sandeep B.
Havaldar, Vijay D.
In vitro absorption studies of acyclovir using natural permeation enhancers
topic_facet Farmacia
acyclovir; aloe vera; chausath prahar pippa; natural permeation enhancer
description Gastroretentive Delivery Systems are employed to improve the bioavailability of drugs which are absorbed through upper part of GIT, by increasing their retention time. Incorporation of permeability enhancers in the formulations of such drugs can further increase their bioavailability; however their use in the formulations is questionable due to the toxicity exhibited by them. Acyclovir is a class III drug having low oral bioavailability due to improper absorption. Mucoadhesive tablets of acyclovir containing natural permeation enhancers were prepared by direct compression and evaluated for mucoadhesion strength, in-vitro dissolution parameters and in-vitro absorption studies. The formulations containing Aloe vera extract showed increase in the mucoadhesion strength and retarded the drug release. The in-vitro absorption studies revealed that the formulations containing Aloe vera extract (Enhancement Ratio 1.94) and chausath prahar pippal (Enhancement Ratio 1.87) showed significant increase in the permeation of the drug. The studies led to the conclusion that by formulating mucoadhesive tablets of acyclovir containing natural permeation enhancers increased the permeability, thus proving to be the cheaper and easily available alternative to the other permeation enhancers.
format Articulo
Articulo
author Dias, Remeth J.
Mali, Kailas K.
Ghorpade, Vishwajeet S.
Garje, Sandeep B.
Havaldar, Vijay D.
author_facet Dias, Remeth J.
Mali, Kailas K.
Ghorpade, Vishwajeet S.
Garje, Sandeep B.
Havaldar, Vijay D.
author_sort Dias, Remeth J.
title In vitro absorption studies of acyclovir using natural permeation enhancers
title_short In vitro absorption studies of acyclovir using natural permeation enhancers
title_full In vitro absorption studies of acyclovir using natural permeation enhancers
title_fullStr In vitro absorption studies of acyclovir using natural permeation enhancers
title_full_unstemmed In vitro absorption studies of acyclovir using natural permeation enhancers
title_sort in vitro absorption studies of acyclovir using natural permeation enhancers
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/8081
http://www.latamjpharm.org/resumenes/29/8/LAJOP_29_8_1_21.pdf
work_keys_str_mv AT diasremethj invitroabsorptionstudiesofacyclovirusingnaturalpermeationenhancers
AT malikailask invitroabsorptionstudiesofacyclovirusingnaturalpermeationenhancers
AT ghorpadevishwajeets invitroabsorptionstudiesofacyclovirusingnaturalpermeationenhancers
AT garjesandeepb invitroabsorptionstudiesofacyclovirusingnaturalpermeationenhancers
AT havaldarvijayd invitroabsorptionstudiesofacyclovirusingnaturalpermeationenhancers
bdutipo_str Repositorios
_version_ 1764820487740850180

Ejemplares similares