Formulation and gastrointestinal transit evaluation of mucoadhesive oral Multiple Unit Systems of Furazolidone

The objective of present study was to improve gastric residence time of furazolidone by preparing mucoadhesive Multiple Unit Systems (MUS) with chitosan, Hydroxypropyl methyl cellulose K4M and sodium carboxymethyl cellulose by employing ionotropic gelation method. The resultant MUS were evaluated in...

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Autores principales: Asane, Govind S., Yamsani, Madhusudan R., Bhatt, Jaykrishna H., Kolhe, Mahesh H., Mukkanti, Khagga
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
chitosan; gastrointestinal transit; multiple unit systems; x-ray
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8080
http://www.latamjpharm.org/resumenes/29/8/LAJOP_29_8_1_20.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8080
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
chitosan; gastrointestinal transit; multiple unit systems; x-ray
spellingShingle Farmacia
chitosan; gastrointestinal transit; multiple unit systems; x-ray
Asane, Govind S.
Yamsani, Madhusudan R.
Bhatt, Jaykrishna H.
Kolhe, Mahesh H.
Mukkanti, Khagga
Formulation and gastrointestinal transit evaluation of mucoadhesive oral Multiple Unit Systems of Furazolidone
topic_facet Farmacia
chitosan; gastrointestinal transit; multiple unit systems; x-ray
description The objective of present study was to improve gastric residence time of furazolidone by preparing mucoadhesive Multiple Unit Systems (MUS) with chitosan, Hydroxypropyl methyl cellulose K4M and sodium carboxymethyl cellulose by employing ionotropic gelation method. The resultant MUS were evaluated in vitro and in vivo. The particle size length ranged between 0.76 ± 0.25 to 0.89 ± 0.23mm, while the breadth was 0.76 ± 0.15 to 0.89 ± 0.06 mm, respectively. Encapsulation efficiency was in range of 82 to 90 %. MUS exhibited good mucoadhesive property in in vitro wash-off test. Stability studies showed no significant change in dissolution profiles (P < 0.05). The Gastrointestinal transit time was determined by fluoroscopic study which revealed that, the MUS retained in gastrointestinal tract for more than 5 hours and distributed throughout GIT. Based upon these results, prepared mucoadhesive MUS can be a good alternative to single unit systems to deliver Furazolidone with improved gastric residence time to treat intestinal amoebiasis.
format Articulo
Articulo
author Asane, Govind S.
Yamsani, Madhusudan R.
Bhatt, Jaykrishna H.
Kolhe, Mahesh H.
Mukkanti, Khagga
author_facet Asane, Govind S.
Yamsani, Madhusudan R.
Bhatt, Jaykrishna H.
Kolhe, Mahesh H.
Mukkanti, Khagga
author_sort Asane, Govind S.
title Formulation and gastrointestinal transit evaluation of mucoadhesive oral Multiple Unit Systems of Furazolidone
title_short Formulation and gastrointestinal transit evaluation of mucoadhesive oral Multiple Unit Systems of Furazolidone
title_full Formulation and gastrointestinal transit evaluation of mucoadhesive oral Multiple Unit Systems of Furazolidone
title_fullStr Formulation and gastrointestinal transit evaluation of mucoadhesive oral Multiple Unit Systems of Furazolidone
title_full_unstemmed Formulation and gastrointestinal transit evaluation of mucoadhesive oral Multiple Unit Systems of Furazolidone
title_sort formulation and gastrointestinal transit evaluation of mucoadhesive oral multiple unit systems of furazolidone
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/8080
http://www.latamjpharm.org/resumenes/29/8/LAJOP_29_8_1_20.pdf
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