Anti-inflammatory effect of diclofenac diethylammonium gel on acute phase of ligature induced periodontitis in rats

This study aimed to evaluate the effect of a diclofenac diethylammonium gel 10 mg/g (DD) on acute phase of ligature induced periodontitis model in rats. Experimental Periodontitis Disease (EPD) was induced in 30 Wistar rats subjected to ligature placement on left molars. Animals were treated with (D...

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Detalles Bibliográficos
Autores principales: Botelho, Marco A., Paixão, Mônica S., Rachid, Ítalo, Bannet, Leonard Edward, Patrus, Ana Helena, Mattos, Thiago Borges, Queiroz, Dinalva, Ruela, Ronaldo, Costa, Jose M. C, Quintans Júnior, Lucindo José
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
diclofenac diethylammonium; inflammation; periodontitis; rats
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8075
http://www.latamjpharm.org/resumenes/29/8/LAJOP_29_8_1_15.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8075
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
diclofenac diethylammonium; inflammation; periodontitis; rats
spellingShingle Farmacia
diclofenac diethylammonium; inflammation; periodontitis; rats
Botelho, Marco A.
Paixão, Mônica S.
Rachid, Ítalo
Bannet, Leonard Edward
Patrus, Ana Helena
Mattos, Thiago Borges
Queiroz, Dinalva
Ruela, Ronaldo
Costa, Jose M. C
Quintans Júnior, Lucindo José
Anti-inflammatory effect of diclofenac diethylammonium gel on acute phase of ligature induced periodontitis in rats
topic_facet Farmacia
diclofenac diethylammonium; inflammation; periodontitis; rats
description This study aimed to evaluate the effect of a diclofenac diethylammonium gel 10 mg/g (DD) on acute phase of ligature induced periodontitis model in rats. Experimental Periodontitis Disease (EPD) was induced in 30 Wistar rats subjected to ligature placement on left molars. Animals were treated with (DD), immediately after (EPD) induction. Saline-based gel (SG) was utilized as negative control and DD gel 10 mg/g was the tested substance. Animals were randomly assigned into the groups. The periodontium and the surrounding gingiva were examined at histopathology, as well as the neutrophil influx into the gingiva was assayed using myeloperoxidase activity levels by ELISA method. DD treatment reduced tissue lesion at histopathology coupled to decreased myeloperoxidase activity production in gingival tissue when compared to the saline gel control group (p < 0.05). The DD gel was able to provide a significant myeloperoxidase decreasing in gingiva tissue confirming to be effective in reducing gingival inflammation in this model.
format Articulo
Articulo
author Botelho, Marco A.
Paixão, Mônica S.
Rachid, Ítalo
Bannet, Leonard Edward
Patrus, Ana Helena
Mattos, Thiago Borges
Queiroz, Dinalva
Ruela, Ronaldo
Costa, Jose M. C
Quintans Júnior, Lucindo José
author_facet Botelho, Marco A.
Paixão, Mônica S.
Rachid, Ítalo
Bannet, Leonard Edward
Patrus, Ana Helena
Mattos, Thiago Borges
Queiroz, Dinalva
Ruela, Ronaldo
Costa, Jose M. C
Quintans Júnior, Lucindo José
author_sort Botelho, Marco A.
title Anti-inflammatory effect of diclofenac diethylammonium gel on acute phase of ligature induced periodontitis in rats
title_short Anti-inflammatory effect of diclofenac diethylammonium gel on acute phase of ligature induced periodontitis in rats
title_full Anti-inflammatory effect of diclofenac diethylammonium gel on acute phase of ligature induced periodontitis in rats
title_fullStr Anti-inflammatory effect of diclofenac diethylammonium gel on acute phase of ligature induced periodontitis in rats
title_full_unstemmed Anti-inflammatory effect of diclofenac diethylammonium gel on acute phase of ligature induced periodontitis in rats
title_sort anti-inflammatory effect of diclofenac diethylammonium gel on acute phase of ligature induced periodontitis in rats
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/8075
http://www.latamjpharm.org/resumenes/29/8/LAJOP_29_8_1_15.pdf
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