Osmotic and activity coefficients of aqueous solutions of the anesthetic drugs lidocaine-HCl and procaine-HCl at 298.15 K
Osmotic and activity coefficients were measured for aqueous solutions of Lidocaine-HCl and Procaine-HCl using the isopiestic method at 298.15 K. The results were fitted to the Pitzer equation and the parameters were calculated. A good correlation with the Pitzer model was found. The osmotic coeffici...
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| Autores principales: | , , , |
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| Formato: | Articulo Comunicacion |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8060 http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_2_7.pdf |
| Aporte de: |
| Sumario: | Osmotic and activity coefficients were measured for aqueous solutions of Lidocaine-HCl and Procaine-HCl using the isopiestic method at 298.15 K. The results were fitted to the Pitzer equation and the parameters were calculated. A good correlation with the Pitzer model was found. The osmotic coefficients thus obtained were analyzed by comparing them with the Debye-Hückel limiting law. The results are discussed in terms of ion-solvent and ion-ion interactions. |
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