Voltammetric determination of melatonin in tablet dosage forms and human serum

The electrochemical oxidation of melatonin is studied in Britton-Robinson buffer in the pH range 2.2-11.8 by cyclic voltammetry at glassy carbon electrode. Three irreversible, diffusion-controlled oxidation peaks were obtained. The utility of using differential pulse and square wave techniques for d...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sayed, Gamal O. el-, Amin, Alaa S.
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2010
Materias:	Farmacia differential pulse voltammetry; melatonin; serum; square-wave voltammetry; tablets; vitamin B6
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8055 http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_2_4.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8055
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia differential pulse voltammetry; melatonin; serum; square-wave voltammetry; tablets; vitamin B6
spellingShingle	Farmacia differential pulse voltammetry; melatonin; serum; square-wave voltammetry; tablets; vitamin B6 Sayed, Gamal O. el- Amin, Alaa S. Voltammetric determination of melatonin in tablet dosage forms and human serum
topic_facet	Farmacia differential pulse voltammetry; melatonin; serum; square-wave voltammetry; tablets; vitamin B6
description	The electrochemical oxidation of melatonin is studied in Britton-Robinson buffer in the pH range 2.2-11.8 by cyclic voltammetry at glassy carbon electrode. Three irreversible, diffusion-controlled oxidation peaks were obtained. The utility of using differential pulse and square wave techniques for determination of melatonin was examined. Different parameters affecting the peak current were analylzed and at optimum conditions, linear calibration plots from 0.02-0.5 mM and 0.04 to 0.5 mM of melatonin were obtained applying the two techniques, respectively. The differential pulse mode was successfully applied to the determination of melatonin in commercial tablets containing about three-folds of vitamin B6 without previous separation. The same technique was also used for melatonin determination in human serum with acceptable accuracy.
format	Articulo Comunicacion
author	Sayed, Gamal O. el- Amin, Alaa S.
author_facet	Sayed, Gamal O. el- Amin, Alaa S.
author_sort	Sayed, Gamal O. el-
title	Voltammetric determination of melatonin in tablet dosage forms and human serum
title_short	Voltammetric determination of melatonin in tablet dosage forms and human serum
title_full	Voltammetric determination of melatonin in tablet dosage forms and human serum
title_fullStr	Voltammetric determination of melatonin in tablet dosage forms and human serum
title_full_unstemmed	Voltammetric determination of melatonin in tablet dosage forms and human serum
title_sort	voltammetric determination of melatonin in tablet dosage forms and human serum
publishDate	2010
url	http://sedici.unlp.edu.ar/handle/10915/8055 http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_2_4.pdf
work_keys_str_mv	AT sayedgamaloel voltammetricdeterminationofmelatoninintabletdosageformsandhumanserum AT aminalaas voltammetricdeterminationofmelatoninintabletdosageformsandhumanserum
bdutipo_str	Repositorios
_version_	1764820487065567233

Voltammetric determination of melatonin in tablet dosage forms and human serum

Ejemplares similares