Validated spectrophotometric methods for simultaneous estimation of acetaminophen, chlorpheniramine maleate and cafeine in pure and tablet dosage form
Two methods for simultaneous estimation of acetaminophen, chlorpheniramine maleate and caffeine in pure and tablet dosage form have been developed. Method I employs formation and solving of simultaneous equation using 246.4 nm, 264.4 nm, and 272 nm as the λ<sub>max</sub> of acetaminoph...
Guardado en:
| Autores principales: | , , |
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| Formato: | Articulo Comunicacion |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8053 http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_2_2.pdf |
| Aporte de: |
| id |
I19-R120-10915-8053 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia acetaminophen; caffeine; chlorpheniramine maleate, ICH guidelines; multi-component method; simultaneous equation method; spectroscopy |
| spellingShingle |
Farmacia acetaminophen; caffeine; chlorpheniramine maleate, ICH guidelines; multi-component method; simultaneous equation method; spectroscopy Joshi, Rupali S. Pawar, Nilima S. Sawant, Ramesh L. Validated spectrophotometric methods for simultaneous estimation of acetaminophen, chlorpheniramine maleate and cafeine in pure and tablet dosage form |
| topic_facet |
Farmacia acetaminophen; caffeine; chlorpheniramine maleate, ICH guidelines; multi-component method; simultaneous equation method; spectroscopy |
| description |
Two methods for simultaneous estimation of acetaminophen, chlorpheniramine maleate and
caffeine in pure and tablet dosage form have been developed. Method I employs formation and solving of
simultaneous equation using 246.4 nm, 264.4 nm, and 272 nm as the λ<sub>max</sub> of acetaminophen, chlorpheniramine
maleate and caffeine respectively in 0.1N HCl. Method II is a multi-component spectrophotometric
analysis in which the instrument is preprogrammed to collect and compile the spectral data from the scan
of standards and produces the result by matrix calculations. These methods are validated for accuracy,
precision, linearity, specificity and sensitivity as per ICH norms. Validation studies are statistically significant.
Calibration curves are linear over the concentration ranges of 5-50 μg/mL for acetaminophen, 5-25
μg/mL for both chlorpheniramine maleate and caffeine. High recovery reveals the reliability of the methods
for quantitative study in tablet formulation. The methods are rapid, cost-effective and can be used as
quality-control tool for routine quantitative analysis of acetaminophen, chlorpheniramine maleate and
caffeine in pure and tablet dosage form. |
| format |
Articulo Comunicacion |
| author |
Joshi, Rupali S. Pawar, Nilima S. Sawant, Ramesh L. |
| author_facet |
Joshi, Rupali S. Pawar, Nilima S. Sawant, Ramesh L. |
| author_sort |
Joshi, Rupali S. |
| title |
Validated spectrophotometric methods for simultaneous estimation of acetaminophen, chlorpheniramine maleate and cafeine in pure and tablet dosage form |
| title_short |
Validated spectrophotometric methods for simultaneous estimation of acetaminophen, chlorpheniramine maleate and cafeine in pure and tablet dosage form |
| title_full |
Validated spectrophotometric methods for simultaneous estimation of acetaminophen, chlorpheniramine maleate and cafeine in pure and tablet dosage form |
| title_fullStr |
Validated spectrophotometric methods for simultaneous estimation of acetaminophen, chlorpheniramine maleate and cafeine in pure and tablet dosage form |
| title_full_unstemmed |
Validated spectrophotometric methods for simultaneous estimation of acetaminophen, chlorpheniramine maleate and cafeine in pure and tablet dosage form |
| title_sort |
validated spectrophotometric methods for simultaneous estimation of acetaminophen, chlorpheniramine maleate and cafeine in pure and tablet dosage form |
| publishDate |
2010 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8053 http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_2_2.pdf |
| work_keys_str_mv |
AT joshirupalis validatedspectrophotometricmethodsforsimultaneousestimationofacetaminophenchlorpheniraminemaleateandcafeineinpureandtabletdosageform AT pawarnilimas validatedspectrophotometricmethodsforsimultaneousestimationofacetaminophenchlorpheniraminemaleateandcafeineinpureandtabletdosageform AT sawantrameshl validatedspectrophotometricmethodsforsimultaneousestimationofacetaminophenchlorpheniraminemaleateandcafeineinpureandtabletdosageform |
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Repositorios |
| _version_ |
1764820487049838592 |