Therapeutic potential of Emblica officinalis L. fruit extract on ischemia reperfusion Injury induced acute renal failure in rat

The present study was designed to explore the ameliorative effect of hydroalcoholic extract of Emblica officinalis (HAE) on renal ischemia reperfusion (I/R) injury induced acute renal failure (ARF). Rats were subjected to administration of HAE (250 and 500 mg/kg, p.o. for 10 days) before one hour...

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Detalles Bibliográficos
Autores principales: Muthuraman, Arunachalam, Sood, Shailja, Gill, Naresh Singh, Arora, Rashmi
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
acute renal failure; anti-oxidant; Emblica officinalis; ischemia-reperfusion
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8050
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_23.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8050
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
acute renal failure; anti-oxidant; Emblica officinalis; ischemia-reperfusion
spellingShingle Farmacia
acute renal failure; anti-oxidant; Emblica officinalis; ischemia-reperfusion
Muthuraman, Arunachalam
Sood, Shailja
Gill, Naresh Singh
Arora, Rashmi
Therapeutic potential of Emblica officinalis L. fruit extract on ischemia reperfusion Injury induced acute renal failure in rat
topic_facet Farmacia
acute renal failure; anti-oxidant; Emblica officinalis; ischemia-reperfusion
description The present study was designed to explore the ameliorative effect of hydroalcoholic extract of Emblica officinalis (HAE) on renal ischemia reperfusion (I/R) injury induced acute renal failure (ARF). Rats were subjected to administration of HAE (250 and 500 mg/kg, p.o. for 10 days) before one hour of the ischemia (30 min) reperfusion (24 h) process on the 10th day of experiment. For evaluating the effect of HAE on acute renal failure, Blood urea nitrogen (BUN) and creatinine (Cr) were estimated in serum sample whereas, N-acetyl β-d-glucosaminidase (NAG) was estimated in urine sample. Further, renal tissue was used to evaluate the oxidative stress markers and histopathological changes. The results demonstrated that I/R caused marked changes in various biomarker levels. However, treatment with HAE significantly attenuated these changes. Histopathological evaluation also revealed protective role of HAE on renal cortex and tubular cells. These effects clearly indicated that HAE produced renoprotective effect against I/R induced acute renal failure
format Articulo
Articulo
author Muthuraman, Arunachalam
Sood, Shailja
Gill, Naresh Singh
Arora, Rashmi
author_facet Muthuraman, Arunachalam
Sood, Shailja
Gill, Naresh Singh
Arora, Rashmi
author_sort Muthuraman, Arunachalam
title Therapeutic potential of Emblica officinalis L. fruit extract on ischemia reperfusion Injury induced acute renal failure in rat
title_short Therapeutic potential of Emblica officinalis L. fruit extract on ischemia reperfusion Injury induced acute renal failure in rat
title_full Therapeutic potential of Emblica officinalis L. fruit extract on ischemia reperfusion Injury induced acute renal failure in rat
title_fullStr Therapeutic potential of Emblica officinalis L. fruit extract on ischemia reperfusion Injury induced acute renal failure in rat
title_full_unstemmed Therapeutic potential of Emblica officinalis L. fruit extract on ischemia reperfusion Injury induced acute renal failure in rat
title_sort therapeutic potential of emblica officinalis l. fruit extract on ischemia reperfusion injury induced acute renal failure in rat
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/8050
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_23.pdf
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