Separation and purification of effective constituents of Rhizoma Paridis saponins by serum pharmacochemistry guiding

Oral administration to rats of Rhizoma Paridis saponins (RPS) from Paris polyphylla var. yunnanensis extracts have been found to show strong anti-tumor activity, but the effective constituents were not known. To detail the effective components in RPS, we investigated the serum pharmacochemistry a...

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Autores principales: Man, Shuli, Gao, Wenyuan, Zhang, Yanjun, Ma, Chaoyi, Huang, Lijing, Li, Yiwen, Liu, Changxiao, Huang, Luqi
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
anti-tumor effect; HPLC-MS; Paris polyphylla; serum pharmacochemistry; steroidal saponin
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8048
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_21.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8048
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
anti-tumor effect; HPLC-MS; Paris polyphylla; serum pharmacochemistry; steroidal saponin
spellingShingle Farmacia
anti-tumor effect; HPLC-MS; Paris polyphylla; serum pharmacochemistry; steroidal saponin
Man, Shuli
Gao, Wenyuan
Zhang, Yanjun
Ma, Chaoyi
Huang, Lijing
Li, Yiwen
Liu, Changxiao
Huang, Luqi
Separation and purification of effective constituents of Rhizoma Paridis saponins by serum pharmacochemistry guiding
topic_facet Farmacia
anti-tumor effect; HPLC-MS; Paris polyphylla; serum pharmacochemistry; steroidal saponin
description Oral administration to rats of Rhizoma Paridis saponins (RPS) from Paris polyphylla var. yunnanensis extracts have been found to show strong anti-tumor activity, but the effective constituents were not known. To detail the effective components in RPS, we investigated the serum pharmacochemistry after oral administration of RPS and detected eight kinds of Paridis saponins in the rat serum. Then we purposefully purified a mixture (PM) from RPS to further research. By comparison of tumor weight, spleen index, antitumor rate and numbers of metastases, PM showed a considerable activity as RPS. In conclusion, the serum pharmacochemistry can help us purposefully to separate and purify RPS and to obtain a potential antitumor agent which may be better than parent drugs.
format Articulo
Articulo
author Man, Shuli
Gao, Wenyuan
Zhang, Yanjun
Ma, Chaoyi
Huang, Lijing
Li, Yiwen
Liu, Changxiao
Huang, Luqi
author_facet Man, Shuli
Gao, Wenyuan
Zhang, Yanjun
Ma, Chaoyi
Huang, Lijing
Li, Yiwen
Liu, Changxiao
Huang, Luqi
author_sort Man, Shuli
title Separation and purification of effective constituents of Rhizoma Paridis saponins by serum pharmacochemistry guiding
title_short Separation and purification of effective constituents of Rhizoma Paridis saponins by serum pharmacochemistry guiding
title_full Separation and purification of effective constituents of Rhizoma Paridis saponins by serum pharmacochemistry guiding
title_fullStr Separation and purification of effective constituents of Rhizoma Paridis saponins by serum pharmacochemistry guiding
title_full_unstemmed Separation and purification of effective constituents of Rhizoma Paridis saponins by serum pharmacochemistry guiding
title_sort separation and purification of effective constituents of rhizoma paridis saponins by serum pharmacochemistry guiding
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/8048
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_21.pdf
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AT gaowenyuan separationandpurificationofeffectiveconstituentsofrhizomaparidissaponinsbyserumpharmacochemistryguiding
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