Comparison of the antioxidant effects of lipid extracts of Roystonea regia (D-004) and saw palmetto on blood oxidative variables of healthy men

D-004, a lipid extract of Roystonea regia fruits that prevents testosterone-induced prostate hyperplasia in rodents, and saw palmetto (SP) lipid extract, used to treat benign prostate hyperplasia, have been shown antioxidant effects. This randomized, double-blind study compared their antioxidant eff...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Rodriguez, Iván, Molina, Vivian, Más, Rosa, Illnait, José, Oyarzábal, Ambar, Mendoza, Sarahí, Fernández, Lilia, Fernández, Julio, Gámez, Rafael, Mesa, Meylis, Jiménez, Sonia, Borrero, Lisete, Cruz, Yadira, Pérez, Yohani
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
antioxidant; benign prostate hyperplasia; D-004; lipid peroxidation; Roystonea regia; saw palmetto
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8047
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_20.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8047
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
antioxidant; benign prostate hyperplasia; D-004; lipid peroxidation; Roystonea regia; saw palmetto
spellingShingle Farmacia
antioxidant; benign prostate hyperplasia; D-004; lipid peroxidation; Roystonea regia; saw palmetto
Rodriguez, Iván
Molina, Vivian
Más, Rosa
Illnait, José
Oyarzábal, Ambar
Mendoza, Sarahí
Fernández, Lilia
Fernández, Julio
Gámez, Rafael
Mesa, Meylis
Jiménez, Sonia
Borrero, Lisete
Cruz, Yadira
Pérez, Yohani
Comparison of the antioxidant effects of lipid extracts of Roystonea regia (D-004) and saw palmetto on blood oxidative variables of healthy men
topic_facet Farmacia
antioxidant; benign prostate hyperplasia; D-004; lipid peroxidation; Roystonea regia; saw palmetto
description D-004, a lipid extract of Roystonea regia fruits that prevents testosterone-induced prostate hyperplasia in rodents, and saw palmetto (SP) lipid extract, used to treat benign prostate hyperplasia, have been shown antioxidant effects. This randomized, double-blind study compared their antioxidant effects in forty healthy men randomised to D-004 or SP (320 mg/day) capsules for 8 weeks. D-004 significantly (p < 0.001) reduced plasma malondialdehyde (MDA) (32.7 %), sulphydril groups (SH-G) (24.6 %) and (p < 0.01) total hydroxyperoxides (TOH) (26.5 %) values and increased (p < 0.001) total antioxidant status (TAS) (44.1 %) and catalase (CAT) (100.0 %) activity. Treatment with SP lowered (p < 0.001) MDA (26.6 %), SH-G (24.1 %), (p < 0.01) TOH (26.3 %) values, and raised (p < 0.001) TAS (57.4 %) and (p < 0.01) CAT (85.7 %) activity. Both treatments were similarly effective and well tolerated. Concluding, D- 004 and SP (320 mg/day) for 8 weeks similarly reduced plasma lipid peroxidation (MDA, TOH) and protein oxidation (SH-G) markers, increased TAS and CAT activity and were well tolerated in healthy men.
format Articulo
Articulo
author Rodriguez, Iván
Molina, Vivian
Más, Rosa
Illnait, José
Oyarzábal, Ambar
Mendoza, Sarahí
Fernández, Lilia
Fernández, Julio
Gámez, Rafael
Mesa, Meylis
Jiménez, Sonia
Borrero, Lisete
Cruz, Yadira
Pérez, Yohani
author_facet Rodriguez, Iván
Molina, Vivian
Más, Rosa
Illnait, José
Oyarzábal, Ambar
Mendoza, Sarahí
Fernández, Lilia
Fernández, Julio
Gámez, Rafael
Mesa, Meylis
Jiménez, Sonia
Borrero, Lisete
Cruz, Yadira
Pérez, Yohani
author_sort Rodriguez, Iván
title Comparison of the antioxidant effects of lipid extracts of Roystonea regia (D-004) and saw palmetto on blood oxidative variables of healthy men
title_short Comparison of the antioxidant effects of lipid extracts of Roystonea regia (D-004) and saw palmetto on blood oxidative variables of healthy men
title_full Comparison of the antioxidant effects of lipid extracts of Roystonea regia (D-004) and saw palmetto on blood oxidative variables of healthy men
title_fullStr Comparison of the antioxidant effects of lipid extracts of Roystonea regia (D-004) and saw palmetto on blood oxidative variables of healthy men
title_full_unstemmed Comparison of the antioxidant effects of lipid extracts of Roystonea regia (D-004) and saw palmetto on blood oxidative variables of healthy men
title_sort comparison of the antioxidant effects of lipid extracts of roystonea regia (d-004) and saw palmetto on blood oxidative variables of healthy men
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/8047
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_20.pdf
work_keys_str_mv AT rodriguezivan comparisonoftheantioxidanteffectsoflipidextractsofroystonearegiad004andsawpalmettoonbloodoxidativevariablesofhealthymen
AT molinavivian comparisonoftheantioxidanteffectsoflipidextractsofroystonearegiad004andsawpalmettoonbloodoxidativevariablesofhealthymen
AT masrosa comparisonoftheantioxidanteffectsoflipidextractsofroystonearegiad004andsawpalmettoonbloodoxidativevariablesofhealthymen
AT illnaitjose comparisonoftheantioxidanteffectsoflipidextractsofroystonearegiad004andsawpalmettoonbloodoxidativevariablesofhealthymen
AT oyarzabalambar comparisonoftheantioxidanteffectsoflipidextractsofroystonearegiad004andsawpalmettoonbloodoxidativevariablesofhealthymen
AT mendozasarahi comparisonoftheantioxidanteffectsoflipidextractsofroystonearegiad004andsawpalmettoonbloodoxidativevariablesofhealthymen
AT fernandezlilia comparisonoftheantioxidanteffectsoflipidextractsofroystonearegiad004andsawpalmettoonbloodoxidativevariablesofhealthymen
AT fernandezjulio comparisonoftheantioxidanteffectsoflipidextractsofroystonearegiad004andsawpalmettoonbloodoxidativevariablesofhealthymen
AT gamezrafael comparisonoftheantioxidanteffectsoflipidextractsofroystonearegiad004andsawpalmettoonbloodoxidativevariablesofhealthymen
AT mesameylis comparisonoftheantioxidanteffectsoflipidextractsofroystonearegiad004andsawpalmettoonbloodoxidativevariablesofhealthymen
AT jimenezsonia comparisonoftheantioxidanteffectsoflipidextractsofroystonearegiad004andsawpalmettoonbloodoxidativevariablesofhealthymen
AT borrerolisete comparisonoftheantioxidanteffectsoflipidextractsofroystonearegiad004andsawpalmettoonbloodoxidativevariablesofhealthymen
AT cruzyadira comparisonoftheantioxidanteffectsoflipidextractsofroystonearegiad004andsawpalmettoonbloodoxidativevariablesofhealthymen
AT perezyohani comparisonoftheantioxidanteffectsoflipidextractsofroystonearegiad004andsawpalmettoonbloodoxidativevariablesofhealthymen
bdutipo_str Repositorios
_version_ 1764820486989021186

Ejemplares similares