Preparation and pharmacokinetic studies of mucoadhesive oral multiple unit systems of metronidazole

The objective of the present study was to investigate the applicability of matrix type chitosan treated alginate multiple unit systems (MUS) for sustained release of metronidazole prepared by ionotropic gelation method. Spherical MUS with 0.64 ± 0.95 to 0.75 ± 0.38 mm length and 0.63 ± 0.34 to 0.74...

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Autores principales: Asane, Govind S., Bhatt, Jaykrishna H., Yamsani, Madhusudan R., Mukkanti, Khagga
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
bioavailability studies; chitosan; gastrointestinal transit; X-ray
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8046
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_19.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8046
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
bioavailability studies; chitosan; gastrointestinal transit; X-ray
spellingShingle Farmacia
bioavailability studies; chitosan; gastrointestinal transit; X-ray
Asane, Govind S.
Bhatt, Jaykrishna H.
Yamsani, Madhusudan R.
Mukkanti, Khagga
Preparation and pharmacokinetic studies of mucoadhesive oral multiple unit systems of metronidazole
topic_facet Farmacia
bioavailability studies; chitosan; gastrointestinal transit; X-ray
description The objective of the present study was to investigate the applicability of matrix type chitosan treated alginate multiple unit systems (MUS) for sustained release of metronidazole prepared by ionotropic gelation method. Spherical MUS with 0.64 ± 0.95 to 0.75 ± 0.38 mm length and 0.63 ± 0.34 to 0.74 ± 0.28 mm breadth and 71.60 ± 0.42 to 82.15 ± 0.35 % entrapment efficiency were produced. The fluoroscopic study reveals that the MUS was retained in gastrointestinal tract (GIT) for more than 5 h and found to be distributed throughout the GIT. The in vivo evaluation in healthy human volunteers of the MUS and that of Flagyl® IR tablets each containing 400 mg drug revealed that the MUS showed improved pharmacokinetic parameters to Flagyl® producing a significantly different (p < 0.05) AUC. This study demonstrates that the MUS could be a good alternative to immediate release tablets to deliver metronidazole and expected to be less irritant to gastric and intestinal mucosa.
format Articulo
Articulo
author Asane, Govind S.
Bhatt, Jaykrishna H.
Yamsani, Madhusudan R.
Mukkanti, Khagga
author_facet Asane, Govind S.
Bhatt, Jaykrishna H.
Yamsani, Madhusudan R.
Mukkanti, Khagga
author_sort Asane, Govind S.
title Preparation and pharmacokinetic studies of mucoadhesive oral multiple unit systems of metronidazole
title_short Preparation and pharmacokinetic studies of mucoadhesive oral multiple unit systems of metronidazole
title_full Preparation and pharmacokinetic studies of mucoadhesive oral multiple unit systems of metronidazole
title_fullStr Preparation and pharmacokinetic studies of mucoadhesive oral multiple unit systems of metronidazole
title_full_unstemmed Preparation and pharmacokinetic studies of mucoadhesive oral multiple unit systems of metronidazole
title_sort preparation and pharmacokinetic studies of mucoadhesive oral multiple unit systems of metronidazole
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/8046
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_19.pdf
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