Evaluation of phytochemical and pharmacological properties of Aegiceras corniculatum Blanco (Myrsinaceae) bark

The methanol extract of the dried barks of Aegiceras corniculatum Blanco (Myrsinaceae) was investigated for its possible antinociceptive, cytotoxic and antidiarrhoeal activities in animal models. The preliminary studies of A. corniculatum bark showed the presence of alkaloids, glycosides, steroids,...

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Autores principales: Bose, Utpal, Bala, Vaskor, Rahman, Ahmed A., Shahid, Israt Z.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
Aegiceras corniculatum; antidiarrhoeal; antinociceptive; cytotoxic; phytochemical study
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8038
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_11.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8038
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Aegiceras corniculatum; antidiarrhoeal; antinociceptive; cytotoxic; phytochemical study
spellingShingle Farmacia
Aegiceras corniculatum; antidiarrhoeal; antinociceptive; cytotoxic; phytochemical study
Bose, Utpal
Bala, Vaskor
Rahman, Ahmed A.
Shahid, Israt Z.
Evaluation of phytochemical and pharmacological properties of Aegiceras corniculatum Blanco (Myrsinaceae) bark
topic_facet Farmacia
Aegiceras corniculatum; antidiarrhoeal; antinociceptive; cytotoxic; phytochemical study
description The methanol extract of the dried barks of Aegiceras corniculatum Blanco (Myrsinaceae) was investigated for its possible antinociceptive, cytotoxic and antidiarrhoeal activities in animal models. The preliminary studies of A. corniculatum bark showed the presence of alkaloids, glycosides, steroids, flavonoids, saponins and tannins. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 250 and 500 mg/kg body weight (P < 0.001) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. The crude extract produced the most prominent cytotoxic activity against brine shrimp Artemia salina (LC50 = 5.5 µg/ml and LC90 = 9.3 µg/ml). The extract showed antidiarrhoeal activity on castor oil induced diarrhoea in mice, it increased mean latent period and decreased the frequency of defecation significantly at the oral dose of 250 and 500 mg/kg body weight (P < 0.01) comparable to the standard drug Loperamide at the dose of 50 mg/kg of body weight. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.
format Articulo
Articulo
author Bose, Utpal
Bala, Vaskor
Rahman, Ahmed A.
Shahid, Israt Z.
author_facet Bose, Utpal
Bala, Vaskor
Rahman, Ahmed A.
Shahid, Israt Z.
author_sort Bose, Utpal
title Evaluation of phytochemical and pharmacological properties of Aegiceras corniculatum Blanco (Myrsinaceae) bark
title_short Evaluation of phytochemical and pharmacological properties of Aegiceras corniculatum Blanco (Myrsinaceae) bark
title_full Evaluation of phytochemical and pharmacological properties of Aegiceras corniculatum Blanco (Myrsinaceae) bark
title_fullStr Evaluation of phytochemical and pharmacological properties of Aegiceras corniculatum Blanco (Myrsinaceae) bark
title_full_unstemmed Evaluation of phytochemical and pharmacological properties of Aegiceras corniculatum Blanco (Myrsinaceae) bark
title_sort evaluation of phytochemical and pharmacological properties of aegiceras corniculatum blanco (myrsinaceae) bark
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/8038
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_11.pdf
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