Antioxidant, antiinflammatory and antiplatelet aggregating activities of Maytenus guyanensis bark extract

In the present study, the bark ethanol extract of Maytenus guyanensis Klotzch (Celastraceae) was investigated for total phenol content, free radical scavenging (DPPH,ABTS, superoxide anion radical and singlet oxygen), antiinflammatory, antiplatelet and antiaggregating activities. M. guyanensis exhib...

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Autores principales: Lima, Emerson S., Vargas, Fabiano de S., Pohlit, Adrián M.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
Maytenus guyanensis; antioxidant; antiplatelet; antiinflammatory
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8035
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_8.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8035
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Maytenus guyanensis; antioxidant; antiplatelet; antiinflammatory
spellingShingle Farmacia
Maytenus guyanensis; antioxidant; antiplatelet; antiinflammatory
Lima, Emerson S.
Vargas, Fabiano de S.
Pohlit, Adrián M.
Antioxidant, antiinflammatory and antiplatelet aggregating activities of Maytenus guyanensis bark extract
topic_facet Farmacia
Maytenus guyanensis; antioxidant; antiplatelet; antiinflammatory
description In the present study, the bark ethanol extract of Maytenus guyanensis Klotzch (Celastraceae) was investigated for total phenol content, free radical scavenging (DPPH,ABTS, superoxide anion radical and singlet oxygen), antiinflammatory, antiplatelet and antiaggregating activities. M. guyanensis exhibited IC50 8.2 ± 0.2, 28.4 ± 0.7, 35.6 ± 3.0 and 517 ± 70.8 µg/mL in the DPPH, ABTS, superoxide and singlet oxygen assays, respectively. Total phenol content was found to be 58.7 ± 1.7 mEq gallic acid (mg/g dry extract). Significant antiinflammatory activity was demonstrated when extract was orally administrated (400 mg/kg b.w.) reducing edema in 40 % when compared with carrageenin. Also, exhibited antiplatelet aggregating activity, with IC50 142 ± 14.3, 133 ± 2.3 and 166 ± 0.3 µg/mL, for platelet aggregation, when induced by adrenalin, adenosine diphosphate or arachidonic acid, respectively. These results suggest that M. guyanensis bark extract could have potential applications in oxidative, inflammatory and homeostasis-related dysfunctions.
format Articulo
Articulo
author Lima, Emerson S.
Vargas, Fabiano de S.
Pohlit, Adrián M.
author_facet Lima, Emerson S.
Vargas, Fabiano de S.
Pohlit, Adrián M.
author_sort Lima, Emerson S.
title Antioxidant, antiinflammatory and antiplatelet aggregating activities of Maytenus guyanensis bark extract
title_short Antioxidant, antiinflammatory and antiplatelet aggregating activities of Maytenus guyanensis bark extract
title_full Antioxidant, antiinflammatory and antiplatelet aggregating activities of Maytenus guyanensis bark extract
title_fullStr Antioxidant, antiinflammatory and antiplatelet aggregating activities of Maytenus guyanensis bark extract
title_full_unstemmed Antioxidant, antiinflammatory and antiplatelet aggregating activities of Maytenus guyanensis bark extract
title_sort antioxidant, antiinflammatory and antiplatelet aggregating activities of maytenus guyanensis bark extract
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/8035
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_8.pdf
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