Genotoxic effect of aqueous extracts from South American Achyrocline and Gnaphalium species (Asteraceae: Gnaphalieae) on human lymphocytes
Crude drug and different extracts of Achyrocline satureioides (Lam.) DC., A. tomentosa Rusby, Gnaphalium cheiranthifolium Lam. and G. gaudichaudianum DC. (Gnaphalieae: Asteraceae) are widely used in South America mainly as digestives and hepatics. These are raw material for phytotherapics preparatio...
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Autores principales: | , , , , |
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Formato: | Articulo |
Lenguaje: | Inglés |
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2010
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Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8032 http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_5.pdf |
Aporte de: |
id |
I19-R120-10915-8032 |
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record_format |
dspace |
institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Farmacia Achyrocline; comet assay; DNA damage; genotoxicity; gnaphalium |
spellingShingle |
Farmacia Achyrocline; comet assay; DNA damage; genotoxicity; gnaphalium Carballo, Marta A. Cortada, Catalina M. Gadano, Andrea B. Del Vitto, Luis A. Petenatti, Elisa M. Genotoxic effect of aqueous extracts from South American Achyrocline and Gnaphalium species (Asteraceae: Gnaphalieae) on human lymphocytes |
topic_facet |
Farmacia Achyrocline; comet assay; DNA damage; genotoxicity; gnaphalium |
description |
Crude drug and different extracts of Achyrocline satureioides (Lam.) DC., A. tomentosa Rusby, Gnaphalium cheiranthifolium Lam. and G. gaudichaudianum DC. (Gnaphalieae: Asteraceae) are widely used in South America mainly as digestives and hepatics. These are raw material for phytotherapics preparations and the manufacture of traditional bitter drinks. In order to establish some aspects on their safety, we have evaluated four different concentrations (1, 10, 100, and 1000 µL.mL-1) of the aqueous extracts of these plants against Single Cell Gel Electrophoresis Assay (SCGEA) in human peripheral blood lymphocytes. Results show a significant increase in damage index (p < 0.001) for all aqueous extracts concentrations assayed of the four plant species, in relation to negative control values. This is a contribution to the development of screenings related to the potential health risk associated with the consumption of South American medicinal plants, especially taking in mind that these plants are widely used as over-thecounter herbs. |
format |
Articulo Articulo |
author |
Carballo, Marta A. Cortada, Catalina M. Gadano, Andrea B. Del Vitto, Luis A. Petenatti, Elisa M. |
author_facet |
Carballo, Marta A. Cortada, Catalina M. Gadano, Andrea B. Del Vitto, Luis A. Petenatti, Elisa M. |
author_sort |
Carballo, Marta A. |
title |
Genotoxic effect of aqueous extracts from South American Achyrocline and Gnaphalium species (Asteraceae: Gnaphalieae) on human lymphocytes |
title_short |
Genotoxic effect of aqueous extracts from South American Achyrocline and Gnaphalium species (Asteraceae: Gnaphalieae) on human lymphocytes |
title_full |
Genotoxic effect of aqueous extracts from South American Achyrocline and Gnaphalium species (Asteraceae: Gnaphalieae) on human lymphocytes |
title_fullStr |
Genotoxic effect of aqueous extracts from South American Achyrocline and Gnaphalium species (Asteraceae: Gnaphalieae) on human lymphocytes |
title_full_unstemmed |
Genotoxic effect of aqueous extracts from South American Achyrocline and Gnaphalium species (Asteraceae: Gnaphalieae) on human lymphocytes |
title_sort |
genotoxic effect of aqueous extracts from south american achyrocline and gnaphalium species (asteraceae: gnaphalieae) on human lymphocytes |
publishDate |
2010 |
url |
http://sedici.unlp.edu.ar/handle/10915/8032 http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_5.pdf |
work_keys_str_mv |
AT carballomartaa genotoxiceffectofaqueousextractsfromsouthamericanachyroclineandgnaphaliumspeciesasteraceaegnaphalieaeonhumanlymphocytes AT cortadacatalinam genotoxiceffectofaqueousextractsfromsouthamericanachyroclineandgnaphaliumspeciesasteraceaegnaphalieaeonhumanlymphocytes AT gadanoandreab genotoxiceffectofaqueousextractsfromsouthamericanachyroclineandgnaphaliumspeciesasteraceaegnaphalieaeonhumanlymphocytes AT delvittoluisa genotoxiceffectofaqueousextractsfromsouthamericanachyroclineandgnaphaliumspeciesasteraceaegnaphalieaeonhumanlymphocytes AT petenattielisam genotoxiceffectofaqueousextractsfromsouthamericanachyroclineandgnaphaliumspeciesasteraceaegnaphalieaeonhumanlymphocytes |
bdutipo_str |
Repositorios |
_version_ |
1764820486838026240 |