Determination of montelukast sodium and levocetirizine dihydrochloride in combined pharmaceutical dosage form by RP-HPLC

A simple, rapid, sensitive and economical method has been developed for the simultaneous determination of montelukast sodium and levocetirizine dihydrochloride in combined tablet dosage form. The method was based on high performance liquid chromatography using zidovudine as an internal standard. The...

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Detalles Bibliográficos
Autores principales: Rote, Ambadas R., Niphade, Vaishali S.
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
column liquid chromatography; levocetirizine dihydrochloride; montelukast sodium; reverse phase; separation
Farmacología
Cromatografia líquida de alta eficiencia
Análisis químico
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8020
http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_2_5.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8020
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
column liquid chromatography; levocetirizine dihydrochloride; montelukast sodium; reverse phase; separation
Farmacología
Cromatografia líquida de alta eficiencia
Análisis químico
spellingShingle Farmacia
column liquid chromatography; levocetirizine dihydrochloride; montelukast sodium; reverse phase; separation
Farmacología
Cromatografia líquida de alta eficiencia
Análisis químico
Rote, Ambadas R.
Niphade, Vaishali S.
Determination of montelukast sodium and levocetirizine dihydrochloride in combined pharmaceutical dosage form by RP-HPLC
topic_facet Farmacia
column liquid chromatography; levocetirizine dihydrochloride; montelukast sodium; reverse phase; separation
Farmacología
Cromatografia líquida de alta eficiencia
Análisis químico
description A simple, rapid, sensitive and economical method has been developed for the simultaneous determination of montelukast sodium and levocetirizine dihydrochloride in combined tablet dosage form. The method was based on high performance liquid chromatography using zidovudine as an internal standard. The separation was carried out with a Eurosphere 100 C18 column (250×4.6 mm ID, 5 μm) and mobile phase 0.05 % orthophosphoric acid: methanol (10:90 v/v) at flow rate 1.2 ml/min. The UV detection was carried out at wavelength 225 nm.The method was validated statistically and by performing recovery study.
format Articulo
Comunicacion
author Rote, Ambadas R.
Niphade, Vaishali S.
author_facet Rote, Ambadas R.
Niphade, Vaishali S.
author_sort Rote, Ambadas R.
title Determination of montelukast sodium and levocetirizine dihydrochloride in combined pharmaceutical dosage form by RP-HPLC
title_short Determination of montelukast sodium and levocetirizine dihydrochloride in combined pharmaceutical dosage form by RP-HPLC
title_full Determination of montelukast sodium and levocetirizine dihydrochloride in combined pharmaceutical dosage form by RP-HPLC
title_fullStr Determination of montelukast sodium and levocetirizine dihydrochloride in combined pharmaceutical dosage form by RP-HPLC
title_full_unstemmed Determination of montelukast sodium and levocetirizine dihydrochloride in combined pharmaceutical dosage form by RP-HPLC
title_sort determination of montelukast sodium and levocetirizine dihydrochloride in combined pharmaceutical dosage form by rp-hplc
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/8020
http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_2_5.pdf
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AT niphadevaishalis determinationofmontelukastsodiumandlevocetirizinedihydrochlorideincombinedpharmaceuticaldosageformbyrphplc
bdutipo_str Repositorios
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