Attainment and characterization of ternary complexes of simvastatin-cyclodextrin-hydrossoluble polymers
The purpose of this study was to attain and characterize ternary complexes of simvastatin, β-cyclodextrin (βCD) and different polymers, and then select those that lead to a greater increase in drug solubility. The complexes were prepared with the co-evaporation method and the polymers used were poly...
Guardado en:
| Autores principales: | , |
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| Formato: | Articulo Comunicacion |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8019 http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_2_4.pdf |
| Aporte de: |
| id |
I19-R120-10915-8019 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia cyclodextrin; simvastatin; ternary complex Farmacología Medicamentos Evaluación de drogas Análisis químico |
| spellingShingle |
Farmacia cyclodextrin; simvastatin; ternary complex Farmacología Medicamentos Evaluación de drogas Análisis químico Takahashi, Andrea I. Ferraz, Humberto G. Attainment and characterization of ternary complexes of simvastatin-cyclodextrin-hydrossoluble polymers |
| topic_facet |
Farmacia cyclodextrin; simvastatin; ternary complex Farmacología Medicamentos Evaluación de drogas Análisis químico |
| description |
The purpose of this study was to attain and characterize ternary complexes of simvastatin, β-cyclodextrin (βCD) and different polymers, and then select those that lead to a greater increase in drug solubility. The complexes were prepared with the co-evaporation method and the polymers used were polyethylene glycol 1500, polyethylene glycol 4000, povidone, copovidone, crospovidone, maltodextrin and hydroxypropyl methyl cellulose. The characterization of complexes was carried out through aqueous solubility, DSC and TG. There was an increase in solubility for all the complexes prepared with βCD and the different polymers, but only when crospovidone and maltodextrin were used was there a significant difference observed between the solubility of the physical mixture and that of the complex. The DSC curves indicate that the non-complexed drug is even in the sample of the complex with higher solubility, thus none of the polymers was able to achieve a total complexation of the drug. |
| format |
Articulo Comunicacion |
| author |
Takahashi, Andrea I. Ferraz, Humberto G. |
| author_facet |
Takahashi, Andrea I. Ferraz, Humberto G. |
| author_sort |
Takahashi, Andrea I. |
| title |
Attainment and characterization of ternary complexes of simvastatin-cyclodextrin-hydrossoluble polymers |
| title_short |
Attainment and characterization of ternary complexes of simvastatin-cyclodextrin-hydrossoluble polymers |
| title_full |
Attainment and characterization of ternary complexes of simvastatin-cyclodextrin-hydrossoluble polymers |
| title_fullStr |
Attainment and characterization of ternary complexes of simvastatin-cyclodextrin-hydrossoluble polymers |
| title_full_unstemmed |
Attainment and characterization of ternary complexes of simvastatin-cyclodextrin-hydrossoluble polymers |
| title_sort |
attainment and characterization of ternary complexes of simvastatin-cyclodextrin-hydrossoluble polymers |
| publishDate |
2010 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8019 http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_2_4.pdf |
| work_keys_str_mv |
AT takahashiandreai attainmentandcharacterizationofternarycomplexesofsimvastatincyclodextrinhydrossolublepolymers AT ferrazhumbertog attainmentandcharacterizationofternarycomplexesofsimvastatincyclodextrinhydrossolublepolymers |
| bdutipo_str |
Repositorios |
| _version_ |
1764820486649282560 |