Formulation and optimization of directly compressible floating tablets of famotidine using 23 factorial design
The aim of the present investigation was to develop a modified release effervescent floating drug delivery system of famotidine for 12 h dosage regimen to improve its bioavailability. Effervescent floating tablets were prepared by direct compression method taking into account its advantages over w...
Guardado en:
| Autores principales: | , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8015 http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_20.pdf |
| Aporte de: |
| id |
I19-R120-10915-8015 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Farmacología carbopol®; direct compression; famotidine; floating tablets; methocel® K15M; 71G; factorial design Medicamentos Vías de administración de drogas Farmacia |
| spellingShingle |
Farmacia Farmacología carbopol®; direct compression; famotidine; floating tablets; methocel® K15M; 71G; factorial design Medicamentos Vías de administración de drogas Farmacia Nalawade, Pravin Somvanshi, Amol Dand, Neha Kadam, Vilasrao Hirlekar, Rajashree Formulation and optimization of directly compressible floating tablets of famotidine using 23 factorial design |
| topic_facet |
Farmacia Farmacología carbopol®; direct compression; famotidine; floating tablets; methocel® K15M; 71G; factorial design Medicamentos Vías de administración de drogas Farmacia |
| description |
The aim of the present investigation was to develop a modified release effervescent floating
drug delivery system of famotidine for 12 h dosage regimen to improve its bioavailability. Effervescent
floating tablets were prepared by direct compression method taking into account its advantages over wet
granulation by using directly compressible excipients like Carbopol® 71G and Cellactose® 80. The incorporation
of sodium bicarbonate aided in the buoyancy with effervescent approach. The prepared tablets
were evaluated for floating lag time (FLT), total floating time (TFT), in vitro drug release along with general
parameters. 23 factorial design was used for optimization. The tablets showed desired release of more
than 98 % over the period of 12 h which may increase bioavailability of selected candidate. The release of
famotidine was found to be influenced by the polymer concentration. Optimized formulation showed acceptable
stability over three months at 40 ºC and 75 % RH. |
| format |
Articulo Articulo |
| author |
Nalawade, Pravin Somvanshi, Amol Dand, Neha Kadam, Vilasrao Hirlekar, Rajashree |
| author_facet |
Nalawade, Pravin Somvanshi, Amol Dand, Neha Kadam, Vilasrao Hirlekar, Rajashree |
| author_sort |
Nalawade, Pravin |
| title |
Formulation and optimization of directly compressible floating tablets of famotidine using 23 factorial design |
| title_short |
Formulation and optimization of directly compressible floating tablets of famotidine using 23 factorial design |
| title_full |
Formulation and optimization of directly compressible floating tablets of famotidine using 23 factorial design |
| title_fullStr |
Formulation and optimization of directly compressible floating tablets of famotidine using 23 factorial design |
| title_full_unstemmed |
Formulation and optimization of directly compressible floating tablets of famotidine using 23 factorial design |
| title_sort |
formulation and optimization of directly compressible floating tablets of famotidine using 23 factorial design |
| publishDate |
2010 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8015 http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_20.pdf |
| work_keys_str_mv |
AT nalawadepravin formulationandoptimizationofdirectlycompressiblefloatingtabletsoffamotidineusing23factorialdesign AT somvanshiamol formulationandoptimizationofdirectlycompressiblefloatingtabletsoffamotidineusing23factorialdesign AT dandneha formulationandoptimizationofdirectlycompressiblefloatingtabletsoffamotidineusing23factorialdesign AT kadamvilasrao formulationandoptimizationofdirectlycompressiblefloatingtabletsoffamotidineusing23factorialdesign AT hirlekarrajashree formulationandoptimizationofdirectlycompressiblefloatingtabletsoffamotidineusing23factorialdesign |
| bdutipo_str |
Repositorios |
| _version_ |
1764820486564347908 |