Development and validation of an UV-spectrophotometric method for the dissolution studies of sitagliptin tablets

A simple UV-spectrophotometric method was developed and validated for the analysis and dissolution studies of sitagliptin phosphate in tablets. Specificity test indicated an adequate UV detection at 267 nm. The method was validated regarding Specificity/accuracy/precision (RSD < 2 %), linearity (...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ravanello, Aline, Dadalt, Gabriele, Torres, Bruna G. S., Hurtado, Felipe K., Marcolino, Ana I. P., Rolim, Clarice M. B.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2010
Materias:	Farmacia dissolution; sitagliptin; UV-spectrophotometry; validation Farmacología Espectrofotometría Medicamentos Evaluación de drogas
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8011 http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_16.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8011
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia dissolution; sitagliptin; UV-spectrophotometry; validation Farmacología Espectrofotometría Medicamentos Evaluación de drogas
spellingShingle	Farmacia dissolution; sitagliptin; UV-spectrophotometry; validation Farmacología Espectrofotometría Medicamentos Evaluación de drogas Ravanello, Aline Dadalt, Gabriele Torres, Bruna G. S. Hurtado, Felipe K. Marcolino, Ana I. P. Rolim, Clarice M. B. Development and validation of an UV-spectrophotometric method for the dissolution studies of sitagliptin tablets
topic_facet	Farmacia dissolution; sitagliptin; UV-spectrophotometry; validation Farmacología Espectrofotometría Medicamentos Evaluación de drogas
description	A simple UV-spectrophotometric method was developed and validated for the analysis and dissolution studies of sitagliptin phosphate in tablets. Specificity test indicated an adequate UV detection at 267 nm. The method was validated regarding Specificity/accuracy/precision (RSD < 2 %), linearity (r2 = 0.9999), and partial robustness. Tablets uniformity was 102.52 % (RSD = 2.54 %). The method was applied for the determination of the drug in commercial tablet preparations and proved to be reliable for quantification It was also used for the comparison of dissolution profiles of sitagliptin tablets. After dissolution tests comparing eight different conditions through dissolution efficiency (DE), the chosen condition for posterior tests was USP apparatus 1 (basket) in 0.01M HCl pH 3.0, at a stirring rate of 50 rpm. The methodology was applied to two batches of sitagliptin phosphate tablets, giving similar dissolution profiles compared by the difference and similarity factor, obtaining values within the specified limits.
format	Articulo Articulo
author	Ravanello, Aline Dadalt, Gabriele Torres, Bruna G. S. Hurtado, Felipe K. Marcolino, Ana I. P. Rolim, Clarice M. B.
author_facet	Ravanello, Aline Dadalt, Gabriele Torres, Bruna G. S. Hurtado, Felipe K. Marcolino, Ana I. P. Rolim, Clarice M. B.
author_sort	Ravanello, Aline
title	Development and validation of an UV-spectrophotometric method for the dissolution studies of sitagliptin tablets
title_short	Development and validation of an UV-spectrophotometric method for the dissolution studies of sitagliptin tablets
title_full	Development and validation of an UV-spectrophotometric method for the dissolution studies of sitagliptin tablets
title_fullStr	Development and validation of an UV-spectrophotometric method for the dissolution studies of sitagliptin tablets
title_full_unstemmed	Development and validation of an UV-spectrophotometric method for the dissolution studies of sitagliptin tablets
title_sort	development and validation of an uv-spectrophotometric method for the dissolution studies of sitagliptin tablets
publishDate	2010
url	http://sedici.unlp.edu.ar/handle/10915/8011 http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_16.pdf
work_keys_str_mv	AT ravanelloaline developmentandvalidationofanuvspectrophotometricmethodforthedissolutionstudiesofsitagliptintablets AT dadaltgabriele developmentandvalidationofanuvspectrophotometricmethodforthedissolutionstudiesofsitagliptintablets AT torresbrunags developmentandvalidationofanuvspectrophotometricmethodforthedissolutionstudiesofsitagliptintablets AT hurtadofelipek developmentandvalidationofanuvspectrophotometricmethodforthedissolutionstudiesofsitagliptintablets AT marcolinoanaip developmentandvalidationofanuvspectrophotometricmethodforthedissolutionstudiesofsitagliptintablets AT rolimclaricemb developmentandvalidationofanuvspectrophotometricmethodforthedissolutionstudiesofsitagliptintablets
bdutipo_str	Repositorios
_version_	1764820487617118209

Development and validation of an UV-spectrophotometric method for the dissolution studies of sitagliptin tablets

Ejemplares similares