Evaluation of oral fast disintegrating tablet of taste masked famotidine in rat
The purpose of this research was to formulate fast-disintegrating tablets of famotidine by using tasteless complex of famotidine. Famotidine is a commonly used antiulcer drug but major disadvantage is its bitterness and low bioavailability. A fast-disintegrating dosage form has been developed as a...
| Autores principales: | , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8009 http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_14.pdf |
| Aporte de: |
| id |
I19-R120-10915-8009 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Farmacia famotidine; oral fast disintegrating tablets; superdisintegrating agent; taste masking Medicamentos Espectroscopía infrarroja Vías de administración de drogas |
| spellingShingle |
Farmacia Farmacia famotidine; oral fast disintegrating tablets; superdisintegrating agent; taste masking Medicamentos Espectroscopía infrarroja Vías de administración de drogas Puri, Dinesh Bhalekar, Mangesh R. Sethi, Sunny S. Evaluation of oral fast disintegrating tablet of taste masked famotidine in rat |
| topic_facet |
Farmacia Farmacia famotidine; oral fast disintegrating tablets; superdisintegrating agent; taste masking Medicamentos Espectroscopía infrarroja Vías de administración de drogas |
| description |
The purpose of this research was to formulate fast-disintegrating tablets of famotidine by using
tasteless complex of famotidine. Famotidine is a commonly used antiulcer drug but major disadvantage
is its bitterness and low bioavailability. A fast-disintegrating dosage form has been developed as a user-
friendly formulation that disintegrates in the mouth immediately. In this study the bitter taste of famotidine
was masked by making complex with ion exchange resin Indion 214. The drug-resin complexes were
characterized by infrared spectroscopy and thermal analysis. Famotidine oral fast disintegrating tablets
were prepared by direct compression method by using different superdisintegrants. The prepared tablets
were found to comply with various official specifications. Tablet containing crospovidone as superdisintegrating
agent showed superior organoleptic properties, along with excellent in vitro disintegrating time
and drug release, as compared to other formulation. The in vivo anti ulcer activity in rats shown that there
was no bioavailability change due to complexation and tablet had good antiulcer activity. |
| format |
Articulo Articulo |
| author |
Puri, Dinesh Bhalekar, Mangesh R. Sethi, Sunny S. |
| author_facet |
Puri, Dinesh Bhalekar, Mangesh R. Sethi, Sunny S. |
| author_sort |
Puri, Dinesh |
| title |
Evaluation of oral fast disintegrating tablet of taste masked famotidine in rat |
| title_short |
Evaluation of oral fast disintegrating tablet of taste masked famotidine in rat |
| title_full |
Evaluation of oral fast disintegrating tablet of taste masked famotidine in rat |
| title_fullStr |
Evaluation of oral fast disintegrating tablet of taste masked famotidine in rat |
| title_full_unstemmed |
Evaluation of oral fast disintegrating tablet of taste masked famotidine in rat |
| title_sort |
evaluation of oral fast disintegrating tablet of taste masked famotidine in rat |
| publishDate |
2010 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8009 http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_14.pdf |
| work_keys_str_mv |
AT puridinesh evaluationoforalfastdisintegratingtabletoftastemaskedfamotidineinrat AT bhalekarmangeshr evaluationoforalfastdisintegratingtabletoftastemaskedfamotidineinrat AT sethisunnys evaluationoforalfastdisintegratingtabletoftastemaskedfamotidineinrat |
| bdutipo_str |
Repositorios |
| _version_ |
1764820487582515200 |