Curcumin-loaded polymeric and lipid nanocapsules: preparation, characterization and chemical stability evaluation

Polymeric and lipid nanocapsules suspensions of the natural compound curcumin were prepared in order to overcome limitations associated with its clinical applications, such as poor aqueous solubility and susceptibility to hydrolytic and photochemical degradation. Nanocapsule suspensions were prepare...

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Detalles Bibliográficos
Autores principales:	Cardoso, Simone Gonçalves, Mazzarino, Letícia, Dora, Cristiana L., Bellettini, Ismael C., Minatti, Edson, Lemos Senna, Elenara
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2010
Materias:	Farmacia Farmacología curcumin; drug delivery systems; nanocapsules Evaluación de drogas Fenómeno químico y farmacológico
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8007 http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_12.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Farmacología curcumin; drug delivery systems; nanocapsules Evaluación de drogas Fenómeno químico y farmacológico
spellingShingle	Farmacia Farmacología curcumin; drug delivery systems; nanocapsules Evaluación de drogas Fenómeno químico y farmacológico Cardoso, Simone Gonçalves Mazzarino, Letícia Dora, Cristiana L. Bellettini, Ismael C. Minatti, Edson Lemos Senna, Elenara Curcumin-loaded polymeric and lipid nanocapsules: preparation, characterization and chemical stability evaluation
topic_facet	Farmacia Farmacología curcumin; drug delivery systems; nanocapsules Evaluación de drogas Fenómeno químico y farmacológico
description	Polymeric and lipid nanocapsules suspensions of the natural compound curcumin were prepared in order to overcome limitations associated with its clinical applications, such as poor aqueous solubility and susceptibility to hydrolytic and photochemical degradation. Nanocapsule suspensions were prepared by nanoprecipitation and phase inversion methods, respectively. The curcumin formulations were investigated for physicochemical characteristics and in vitro drug release. The hydrolytic and photochemical degradation of the drug associated with the nanocarriers was also determined. For all formulations, the entrapment efficiency values were higher than 99 %. The aqueous colloidal suspensions of curcumin resulted in an increase in drug concentration by a factor of up to 46.103 times. Moreover, stability studies indicated that nanoencapsulation slows down the hydrolytic and photochemical degradations of curcumin. The strategy of nanoencapsulation into polymeric and lipid nanocapsules produced a formulation of curcumin with high drug loading and improved stability, representing a good strategy for the delivery of this drug.
format	Articulo Articulo
author	Cardoso, Simone Gonçalves Mazzarino, Letícia Dora, Cristiana L. Bellettini, Ismael C. Minatti, Edson Lemos Senna, Elenara
author_facet	Cardoso, Simone Gonçalves Mazzarino, Letícia Dora, Cristiana L. Bellettini, Ismael C. Minatti, Edson Lemos Senna, Elenara
author_sort	Cardoso, Simone Gonçalves
title	Curcumin-loaded polymeric and lipid nanocapsules: preparation, characterization and chemical stability evaluation
title_short	Curcumin-loaded polymeric and lipid nanocapsules: preparation, characterization and chemical stability evaluation
title_full	Curcumin-loaded polymeric and lipid nanocapsules: preparation, characterization and chemical stability evaluation
title_fullStr	Curcumin-loaded polymeric and lipid nanocapsules: preparation, characterization and chemical stability evaluation
title_full_unstemmed	Curcumin-loaded polymeric and lipid nanocapsules: preparation, characterization and chemical stability evaluation
title_sort	curcumin-loaded polymeric and lipid nanocapsules: preparation, characterization and chemical stability evaluation
publishDate	2010
url	http://sedici.unlp.edu.ar/handle/10915/8007 http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_12.pdf
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bdutipo_str	Repositorios
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Curcumin-loaded polymeric and lipid nanocapsules: preparation, characterization and chemical stability evaluation

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