Antioxidant, anti-inflammatory and analgesic potential of Cucumis sativus seed extract

In the present study antioxidant, anti-inflammatory and analgesic potential of the methanolic extract of Cucumis sativus seeds was evaluated. Extraction of the seeds was carried out using solvents of increasing polarity. The free radical scavenging activity of all the extracts was measured by DPPH a...

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Detalles Bibliográficos
Autores principales:	Singh Gill, Naresh, Sood, Shailja, Muthuraman, Arunachalam, Garg, Manju, Kumar, Raman, Bali, Manoj, Dev Sharma, Pritam
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2010
Materias:	Farmacia antioxidant; anti-inflammatory; analgesic; Cucumis sativus; free radical; hydrogen peroxide Farmacología Extractos de plantas Antioxidantes Analgésicos
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8006 http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_11.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia antioxidant; anti-inflammatory; analgesic; Cucumis sativus; free radical; hydrogen peroxide Farmacología Extractos de plantas Antioxidantes Analgésicos
spellingShingle	Farmacia antioxidant; anti-inflammatory; analgesic; Cucumis sativus; free radical; hydrogen peroxide Farmacología Extractos de plantas Antioxidantes Analgésicos Singh Gill, Naresh Sood, Shailja Muthuraman, Arunachalam Garg, Manju Kumar, Raman Bali, Manoj Dev Sharma, Pritam Antioxidant, anti-inflammatory and analgesic potential of Cucumis sativus seed extract
topic_facet	Farmacia antioxidant; anti-inflammatory; analgesic; Cucumis sativus; free radical; hydrogen peroxide Farmacología Extractos de plantas Antioxidantes Analgésicos
description	In the present study antioxidant, anti-inflammatory and analgesic potential of the methanolic extract of Cucumis sativus seeds was evaluated. Extraction of the seeds was carried out using solvents of increasing polarity. The free radical scavenging activity of all the extracts was measured by DPPH and H2O2 methods. Methanolic extract of the seeds had shown significant antioxidant activity as compared to chloroform and ethyl acetate extract. Hence, methanolic extract of C. sativus seeds (MECS) at a dose level of 100, 200 and 300 mg/kg was further evaluated for its in vivo anti-inflammatory activity using carrageenan induced rat paw edema and analgesic activity by tail flick and tail immersion methods. Results were obtained in a dose dependent manner. MECS (300 mg/kg) had shown significant (p < 0.05) anti-inflammatory and analgesic activity as compared to diclofenac sodium and morphine, respectively. From the results it may be concluded that MECS have good antioxidant, anti-inflammatory and analgesic potential.
format	Articulo Articulo
author	Singh Gill, Naresh Sood, Shailja Muthuraman, Arunachalam Garg, Manju Kumar, Raman Bali, Manoj Dev Sharma, Pritam
author_facet	Singh Gill, Naresh Sood, Shailja Muthuraman, Arunachalam Garg, Manju Kumar, Raman Bali, Manoj Dev Sharma, Pritam
author_sort	Singh Gill, Naresh
title	Antioxidant, anti-inflammatory and analgesic potential of Cucumis sativus seed extract
title_short	Antioxidant, anti-inflammatory and analgesic potential of Cucumis sativus seed extract
title_full	Antioxidant, anti-inflammatory and analgesic potential of Cucumis sativus seed extract
title_fullStr	Antioxidant, anti-inflammatory and analgesic potential of Cucumis sativus seed extract
title_full_unstemmed	Antioxidant, anti-inflammatory and analgesic potential of Cucumis sativus seed extract
title_sort	antioxidant, anti-inflammatory and analgesic potential of cucumis sativus seed extract
publishDate	2010
url	http://sedici.unlp.edu.ar/handle/10915/8006 http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_11.pdf
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bdutipo_str	Repositorios
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Antioxidant, anti-inflammatory and analgesic potential of Cucumis sativus seed extract

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