Ileo-cecal targeting mucoadhesive budesonide tablet
Crohn's disease occurs at any part of gastro-intestinal tract (GIT) but the most susceptible is the ileo-cecal region. For an effective treatment of this disease is essential the drug to be released at ileo-cecal region for an extended period of time. The present study is an attempt to design...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8002 http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_7.pdf |
| Aporte de: |
| id |
I19-R120-10915-8002 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Farmacología carbopol 974 P; eudragit S100; HPMC K100M; Ileo-cecal targeting; in vivo X-ray study Enfermedades gastrointestinales Vías de administración de drogas Química farmacéutica |
| spellingShingle |
Farmacia Farmacología carbopol 974 P; eudragit S100; HPMC K100M; Ileo-cecal targeting; in vivo X-ray study Enfermedades gastrointestinales Vías de administración de drogas Química farmacéutica Kshirsagar, Sanjay J. Gupta, Sunil R. Bhalekar, Mangesh R. Wadekar, Sharad B. Supe, Santosh Ileo-cecal targeting mucoadhesive budesonide tablet |
| topic_facet |
Farmacia Farmacología carbopol 974 P; eudragit S100; HPMC K100M; Ileo-cecal targeting; in vivo X-ray study Enfermedades gastrointestinales Vías de administración de drogas Química farmacéutica |
| description |
Crohn's disease occurs at any part of gastro-intestinal tract (GIT) but the most susceptible is
the ileo-cecal region. For an effective treatment of this disease is essential the drug to be released at ileo-cecal
region for an extended period of time. The present study is an attempt to design and develop an ileo-cecal
targeting mucoadhesive drug delivery system that may be released specifically and slowly in ileo-cecal
region without being released in the upper GIT for an extended period of time (12 h). Budesonide mucoadhesive
tablets are coated with Eudragit S100, which is a polymer that specifically dissolves at and above
pH 6.8. The in vitro drug release by changing pH method was done and in vivo study using X-ray radiography
was carried out to ascertain the position of tablets in GIT after specific time intervals. The in vitro
performance of the tablet with 10 % w/w coating level showed that the tablet did not disintegrate till 16 h
with constant drug release. An in vivo study also reveals that the tablet lasted till 16 h in the ileo-cecal region. |
| format |
Articulo Articulo |
| author |
Kshirsagar, Sanjay J. Gupta, Sunil R. Bhalekar, Mangesh R. Wadekar, Sharad B. Supe, Santosh |
| author_facet |
Kshirsagar, Sanjay J. Gupta, Sunil R. Bhalekar, Mangesh R. Wadekar, Sharad B. Supe, Santosh |
| author_sort |
Kshirsagar, Sanjay J. |
| title |
Ileo-cecal targeting mucoadhesive budesonide tablet |
| title_short |
Ileo-cecal targeting mucoadhesive budesonide tablet |
| title_full |
Ileo-cecal targeting mucoadhesive budesonide tablet |
| title_fullStr |
Ileo-cecal targeting mucoadhesive budesonide tablet |
| title_full_unstemmed |
Ileo-cecal targeting mucoadhesive budesonide tablet |
| title_sort |
ileo-cecal targeting mucoadhesive budesonide tablet |
| publishDate |
2010 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8002 http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_7.pdf |
| work_keys_str_mv |
AT kshirsagarsanjayj ileocecaltargetingmucoadhesivebudesonidetablet AT guptasunilr ileocecaltargetingmucoadhesivebudesonidetablet AT bhalekarmangeshr ileocecaltargetingmucoadhesivebudesonidetablet AT wadekarsharadb ileocecaltargetingmucoadhesivebudesonidetablet AT supesantosh ileocecaltargetingmucoadhesivebudesonidetablet |
| bdutipo_str |
Repositorios |
| _version_ |
1764820487489191936 |