Zinc Oxide Nanoparticles and Photodynamic Therapy for the Treatment of B-chronic Lymphocytic Leukemia

The generation of singlet oxygen (SO) in the presence of specific photosensitizers (PS) or semiconductor nanoparticles (NPs) and its application in photodynamic therapy (PDT) has great interest for the development of new cancer therapies. Our work focused on the identification of factors leading to...

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Autores principales: Loydover Peña Luengas, Sandra, Marín, Gustavo Horacio, Rivera, Luis, Tarditti, Adrián, Roque, Gustavo, Mansilla, Eduardo, Guenova, Margarita, Balatzenko, Gueorgui
Formato: Libro Capitulo de libro
Lenguaje:Inglés
Publicado: Intech 2015
Materias:
Ciencias Médicas
ZnO, Naoparticles, PDT, Leukemia
Leucemia
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/80008
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-80008
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
ZnO, Naoparticles, PDT, Leukemia
Leucemia
spellingShingle Ciencias Médicas
ZnO, Naoparticles, PDT, Leukemia
Leucemia
Loydover Peña Luengas, Sandra
Marín, Gustavo Horacio
Rivera, Luis
Tarditti, Adrián
Roque, Gustavo
Mansilla, Eduardo
Guenova, Margarita
Balatzenko, Gueorgui
Zinc Oxide Nanoparticles and Photodynamic Therapy for the Treatment of B-chronic Lymphocytic Leukemia
topic_facet Ciencias Médicas
ZnO, Naoparticles, PDT, Leukemia
Leucemia
description The generation of singlet oxygen (SO) in the presence of specific photosensitizers (PS) or semiconductor nanoparticles (NPs) and its application in photodynamic therapy (PDT) has great interest for the development of new cancer therapies. Our work focused on the identification of factors leading to the enhancement of B-Chronic Lymphocytic Leukemia (B-CLL) intracellular SO production and cell killing using Manganese (Mn) doped and undoped Zinc Oxide (ZnO) NPs as potential photosensitizers with and without PDT. Mn can enhance ZnO NPs generation of SO by targeted cells. Multi drug resistant B-Chronic Lymphocytic Leukemia (B-CLL) cells spontaneously produce high amounts of Reactive Oxygen Species (ROS) having an altered redox state in relation to that of normal B lymphocytes. These little variations of its SO intracellular concentrations could allow ZnO NPs to execute specific deadly programs against these leukemic cells with no significant damage to normal lymphocytes. A 0.5% Mn Doped ZnO NP was finally selected for further probes as it had the best killing activity in fludarabine resistant B-CLL cells, especially when combined with PDT. This could be an innovative specific therapy against resistant B-CLL probably contributing in the near future for the definitive benefit of these bad prognostic patients.
format Libro
Capitulo de libro
author Loydover Peña Luengas, Sandra
Marín, Gustavo Horacio
Rivera, Luis
Tarditti, Adrián
Roque, Gustavo
Mansilla, Eduardo
Guenova, Margarita
Balatzenko, Gueorgui
author_facet Loydover Peña Luengas, Sandra
Marín, Gustavo Horacio
Rivera, Luis
Tarditti, Adrián
Roque, Gustavo
Mansilla, Eduardo
Guenova, Margarita
Balatzenko, Gueorgui
author_sort Loydover Peña Luengas, Sandra
title Zinc Oxide Nanoparticles and Photodynamic Therapy for the Treatment of B-chronic Lymphocytic Leukemia
title_short Zinc Oxide Nanoparticles and Photodynamic Therapy for the Treatment of B-chronic Lymphocytic Leukemia
title_full Zinc Oxide Nanoparticles and Photodynamic Therapy for the Treatment of B-chronic Lymphocytic Leukemia
title_fullStr Zinc Oxide Nanoparticles and Photodynamic Therapy for the Treatment of B-chronic Lymphocytic Leukemia
title_full_unstemmed Zinc Oxide Nanoparticles and Photodynamic Therapy for the Treatment of B-chronic Lymphocytic Leukemia
title_sort zinc oxide nanoparticles and photodynamic therapy for the treatment of b-chronic lymphocytic leukemia
publisher Intech
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/80008
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bdutipo_str Repositorios
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