Adsorption of paracetamol on activated charcoal in the presence of dextropropoxyphene hydrochloride, N-acetylcysteine and sorbitol

Paracetamol, an over the counter analgesic and antipyretic drug, causes hepatic and renal tubular necrosis at higher doses ingested accidentally, or intentionally. The situation worsens clinically upon the ingestion of product containing paracetamol and dextropropoxyphene. In paracetamol poisoning,...

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Autores principales:	Hussain, Khalid, Bukhari, Nadeem I., Danish, Muhammad Z., Hassan, Syed S., Tanveer, Muhammad
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2010
Materias:	Farmacia paracetamol; activated charcoal; dextroprpoxyphene,N-acetylcysteine; sorbitol Farmacología Medicamentos Analgésicos Efectos fisiológicos de las drogas Evaluación de drogas
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8000 http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_5.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8000
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia paracetamol; activated charcoal; dextroprpoxyphene,N-acetylcysteine; sorbitol Farmacología Medicamentos Analgésicos Efectos fisiológicos de las drogas Evaluación de drogas
spellingShingle	Farmacia paracetamol; activated charcoal; dextroprpoxyphene,N-acetylcysteine; sorbitol Farmacología Medicamentos Analgésicos Efectos fisiológicos de las drogas Evaluación de drogas Hussain, Khalid Bukhari, Nadeem I. Danish, Muhammad Z. Hassan, Syed S. Tanveer, Muhammad Adsorption of paracetamol on activated charcoal in the presence of dextropropoxyphene hydrochloride, N-acetylcysteine and sorbitol
topic_facet	Farmacia paracetamol; activated charcoal; dextroprpoxyphene,N-acetylcysteine; sorbitol Farmacología Medicamentos Analgésicos Efectos fisiológicos de las drogas Evaluación de drogas
description	Paracetamol, an over the counter analgesic and antipyretic drug, causes hepatic and renal tubular necrosis at higher doses ingested accidentally, or intentionally. The situation worsens clinically upon the ingestion of product containing paracetamol and dextropropoxyphene. In paracetamol poisoning, activated charcoal is used to adsorb the drug from the gastrointestinal tract, sorbitol to remove charcoaldrug complexes and N-acetylcysteine to reduce the drug and its metabolites from systemic circulation. Activated charcoal being non-specific adsorbent may adsorb other chemical moieties from the intestine as well as antidotes. Therefore, the present study aimed to investigate the adsorption of paracetamol on activated charcoal in presence of dextropropoxyphene hydrochloride, N-acetylcysteine and sorbitol. Paracetamol was combined separately with dextropropoxyphene hydrochloride, N-acetylcysteine and sorbitol. These mixtures were combined with varying amounts of activated charcoal to evaluate the in vitro adsorption of paracetamol using Langmuir Isotherm. Paracetamol adsorption was 96.6 % at charcoal-drug ratio (6:1) while only 2 % higher in 8:1 and 2.9 % in 10:1. The binding constant (K2), maximum adsorption capacity per gram of activated charcoal for paracetamol alone and in presence of dextropropoxyphene hydrochloride, N-acetylcysteine and sorbitol was found to be 366, 339, 313 and 355 mg/g, respectively. The results of the present study indicate that except sorbitol other investigated substances significantly reduce the adsorption of paracetamol on activated charcoal, which may be compensated by increasing the concentration of activated charcoal.
format	Articulo Articulo
author	Hussain, Khalid Bukhari, Nadeem I. Danish, Muhammad Z. Hassan, Syed S. Tanveer, Muhammad
author_facet	Hussain, Khalid Bukhari, Nadeem I. Danish, Muhammad Z. Hassan, Syed S. Tanveer, Muhammad
author_sort	Hussain, Khalid
title	Adsorption of paracetamol on activated charcoal in the presence of dextropropoxyphene hydrochloride, N-acetylcysteine and sorbitol
title_short	Adsorption of paracetamol on activated charcoal in the presence of dextropropoxyphene hydrochloride, N-acetylcysteine and sorbitol
title_full	Adsorption of paracetamol on activated charcoal in the presence of dextropropoxyphene hydrochloride, N-acetylcysteine and sorbitol
title_fullStr	Adsorption of paracetamol on activated charcoal in the presence of dextropropoxyphene hydrochloride, N-acetylcysteine and sorbitol
title_full_unstemmed	Adsorption of paracetamol on activated charcoal in the presence of dextropropoxyphene hydrochloride, N-acetylcysteine and sorbitol
title_sort	adsorption of paracetamol on activated charcoal in the presence of dextropropoxyphene hydrochloride, n-acetylcysteine and sorbitol
publishDate	2010
url	http://sedici.unlp.edu.ar/handle/10915/8000 http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_5.pdf
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bdutipo_str	Repositorios
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Adsorption of paracetamol on activated charcoal in the presence of dextropropoxyphene hydrochloride, N-acetylcysteine and sorbitol

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