Ion activated in situ gel system for ophthalmic delivery of moxifloxacin hydrochloride

Rapid precorneal elimination of drug is a major limitation of conventional ophthalmic formulations. An ion activated in situ gel forming systems of an antibacterial agent moxifloxacin hydrochloride for instillation as drops into eye undergoing a sol to gel transition in the cul-de-sac was formulated...

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Autores principales: Mali, Mahesh N., Hajare, Ashok A.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
Farmacología
draize eye irritation; in situ gel; moxifloxacin hydrochloride
Evaluación de drogas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7999
http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_4.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7999
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Farmacología
draize eye irritation; in situ gel; moxifloxacin hydrochloride
Evaluación de drogas
spellingShingle Farmacia
Farmacología
draize eye irritation; in situ gel; moxifloxacin hydrochloride
Evaluación de drogas
Mali, Mahesh N.
Hajare, Ashok A.
Ion activated in situ gel system for ophthalmic delivery of moxifloxacin hydrochloride
topic_facet Farmacia
Farmacología
draize eye irritation; in situ gel; moxifloxacin hydrochloride
Evaluación de drogas
description Rapid precorneal elimination of drug is a major limitation of conventional ophthalmic formulations. An ion activated in situ gel forming systems of an antibacterial agent moxifloxacin hydrochloride for instillation as drops into eye undergoing a sol to gel transition in the cul-de-sac was formulated. Sodium alginate was used as the gelling agent in combination with hydroxypropylmethyl cellulose. Formulations were evaluated for gelling capacity, pH, in vitro release, rheological study, Draize eye irritation test and storage stability. Systems exhibited pseudoplastic rheology, evidenced by shear thinning with increase in shear stress and increased angular velocity. The in vitro release rate of moxifloxacin hydrochloride from gel decreased as an inverse function of polymer concentration. The optimized products were stable and non irritant. Equal amounts of sodium alginate and hydroxypropylmethyl cellulose exhibit encouraging rheological properties with therapeutically effective and non-irritant product. This in situ gel system can be a viable alternative to conventional eye drops.
format Articulo
Articulo
author Mali, Mahesh N.
Hajare, Ashok A.
author_facet Mali, Mahesh N.
Hajare, Ashok A.
author_sort Mali, Mahesh N.
title Ion activated in situ gel system for ophthalmic delivery of moxifloxacin hydrochloride
title_short Ion activated in situ gel system for ophthalmic delivery of moxifloxacin hydrochloride
title_full Ion activated in situ gel system for ophthalmic delivery of moxifloxacin hydrochloride
title_fullStr Ion activated in situ gel system for ophthalmic delivery of moxifloxacin hydrochloride
title_full_unstemmed Ion activated in situ gel system for ophthalmic delivery of moxifloxacin hydrochloride
title_sort ion activated in situ gel system for ophthalmic delivery of moxifloxacin hydrochloride
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/7999
http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_4.pdf
work_keys_str_mv AT malimaheshn ionactivatedinsitugelsystemforophthalmicdeliveryofmoxifloxacinhydrochloride
AT hajareashoka ionactivatedinsitugelsystemforophthalmicdeliveryofmoxifloxacinhydrochloride
bdutipo_str Repositorios
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