In vitro evaluation of commercially available theophylline sustained release tablets in Pakistan

The dissolution behavior of five commercially available brands of sustained release theophylline tablets was studied in phosphate buffer solutions of pH 1.2, 4.5, 5.5, 6.0 and 7.5 at 37 °C using the USP dissolution apparatus II (paddle method). Drug concentration in the samples was determined spec...

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Autores principales: Ranjha, Nazar M., Mudassir, Jahanzeb, Abbas, Tanveer, Siam, Mohammad A.F., Hussain, Abid
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
in vitro studies; sustained release; tablets; theophylline
Farmacología
In vitro
Medicamentos
Disolución
Espectrofotometría
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7998
http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_3.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7998
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
in vitro studies; sustained release; tablets; theophylline
Farmacología
In vitro
Medicamentos
Disolución
Espectrofotometría
spellingShingle Farmacia
in vitro studies; sustained release; tablets; theophylline
Farmacología
In vitro
Medicamentos
Disolución
Espectrofotometría
Ranjha, Nazar M.
Mudassir, Jahanzeb
Abbas, Tanveer
Siam, Mohammad A.F.
Hussain, Abid
In vitro evaluation of commercially available theophylline sustained release tablets in Pakistan
topic_facet Farmacia
in vitro studies; sustained release; tablets; theophylline
Farmacología
In vitro
Medicamentos
Disolución
Espectrofotometría
description The dissolution behavior of five commercially available brands of sustained release theophylline tablets was studied in phosphate buffer solutions of pH 1.2, 4.5, 5.5, 6.0 and 7.5 at 37 °C using the USP dissolution apparatus II (paddle method). Drug concentration in the samples was determined spectrophotometrically at 272 nm. For predicting the release characteristics of theophylline from selected commercially available tablets the data obtained in the dissolution studies was fitted into various mathematic models defining kinetic parameters of drug release like zero-order rate equation, first-order rate equation, Hixen-crowell cube root law, Higuchi equation and Korsemeyer-Peppas model. Tablets were subjected to weight variation test, hardness, drug content and in vitro release studies. The present study revealed that drug release increases with the increase of pH of the dissolution medium and also varies from brand to brand. Among the five selected brands, B1 and B4 showed better pH dependency and drug release behaviour. It has been suggested that possible reasons for difference in dissolution or drug release behaviour are the difference in the manufacturing techniques and the quantity of hydrophobic excepients used by different manufacturers, which retard the penetration of dissolution medium and ultimately decreases availability of drug in the solution.
format Articulo
Articulo
author Ranjha, Nazar M.
Mudassir, Jahanzeb
Abbas, Tanveer
Siam, Mohammad A.F.
Hussain, Abid
author_facet Ranjha, Nazar M.
Mudassir, Jahanzeb
Abbas, Tanveer
Siam, Mohammad A.F.
Hussain, Abid
author_sort Ranjha, Nazar M.
title In vitro evaluation of commercially available theophylline sustained release tablets in Pakistan
title_short In vitro evaluation of commercially available theophylline sustained release tablets in Pakistan
title_full In vitro evaluation of commercially available theophylline sustained release tablets in Pakistan
title_fullStr In vitro evaluation of commercially available theophylline sustained release tablets in Pakistan
title_full_unstemmed In vitro evaluation of commercially available theophylline sustained release tablets in Pakistan
title_sort in vitro evaluation of commercially available theophylline sustained release tablets in pakistan
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/7998
http://www.latamjpharm.org/resumenes/29/6/LAJOP_29_6_1_3.pdf
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AT abbastanveer invitroevaluationofcommerciallyavailabletheophyllinesustainedreleasetabletsinpakistan
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