Determination of tolbutamide in rabbit plasma by LC-MS/MS and its application to pharmacokinetic study

A sensitive and selective liquid chromatography-tandem mass spectrometry method (LC-MS/MS) for the determination of tolbutamide in rabbit plasma was developed and validated over the concentration range of 4-1000 ng mL-1. After addition of bupivacaine as internal standard (IS), a simplified protei...

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Detalles Bibliográficos
Autores principales: Wang, Xuebao, Lin, Guanyang, Hu, Lufeng, Xu, Xuegu, Jiang, Haiyan, Pan, Yibin, Wang, Xianqin
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
plasma; pharmacokinetics; tolbutamide
Medicamentos
Farmacología
Cromatografía líquida
Monitoreo de drogas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7983
http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_2_1.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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