Antioxidant activity and acute oral toxicity of Phrygilanthus acutifolius flowers
Antioxidant activity of ethanol and water extracts and infusion of the flowers of Phrygilanthus acutifolius were evaluated. Total phenolic contents were determined using Folin- Ciocalteau reagent. The ethanol extract was more effective in scavenging radical 1,1 biphenyl -2-picrylhydrazyl (DPPH), wit...
Guardado en:
| Autores principales: | , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7982 http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_21.pdf |
| Aporte de: |
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I19-R120-10915-7982 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia acute toxicity; antioxidant activity; Phrygilanthus acutifolius Farmacología Extractos de plantas Antioxidantes Tests de toxicidad aguda |
| spellingShingle |
Farmacia acute toxicity; antioxidant activity; Phrygilanthus acutifolius Farmacología Extractos de plantas Antioxidantes Tests de toxicidad aguda Daud, Adriana Reynoso, Marcos Habib, Natalia Sánchez Riera, Alicia Antioxidant activity and acute oral toxicity of Phrygilanthus acutifolius flowers |
| topic_facet |
Farmacia acute toxicity; antioxidant activity; Phrygilanthus acutifolius Farmacología Extractos de plantas Antioxidantes Tests de toxicidad aguda |
| description |
Antioxidant activity of ethanol and water extracts and infusion of the flowers of Phrygilanthus acutifolius were evaluated. Total phenolic contents were determined using Folin- Ciocalteau reagent. The ethanol extract was more effective in scavenging radical 1,1 biphenyl -2-picrylhydrazyl (DPPH), with lower IC50 values. The water and ethanol extracts were the most effective antioxidants based on the inhibition of lipid peroxidation (β carotene bleaching method). The acute toxicity test in rats indicated that oral administration of 3.200 mg/Kg of flowers produced neither mortality, nor changes in behaviour or any other physiological activities. There were no significant differences in the body and organ weight between controls and treated animals. In blood chemistry analysis, aspartate transaminase, alanine transaminase, and alkaline phosphatase activities, no significant changes occurred. In view of the doses consumed empirically in traditional medicine of Amaicha del Valle, Tucumán, Argentina, there is a wide margin of safety for the therapeutic use of Phrygilanthus acutifolius flowers. |
| format |
Articulo Articulo |
| author |
Daud, Adriana Reynoso, Marcos Habib, Natalia Sánchez Riera, Alicia |
| author_facet |
Daud, Adriana Reynoso, Marcos Habib, Natalia Sánchez Riera, Alicia |
| author_sort |
Daud, Adriana |
| title |
Antioxidant activity and acute oral toxicity of Phrygilanthus acutifolius flowers |
| title_short |
Antioxidant activity and acute oral toxicity of Phrygilanthus acutifolius flowers |
| title_full |
Antioxidant activity and acute oral toxicity of Phrygilanthus acutifolius flowers |
| title_fullStr |
Antioxidant activity and acute oral toxicity of Phrygilanthus acutifolius flowers |
| title_full_unstemmed |
Antioxidant activity and acute oral toxicity of Phrygilanthus acutifolius flowers |
| title_sort |
antioxidant activity and acute oral toxicity of phrygilanthus acutifolius flowers |
| publishDate |
2010 |
| url |
http://sedici.unlp.edu.ar/handle/10915/7982 http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_21.pdf |
| work_keys_str_mv |
AT daudadriana antioxidantactivityandacuteoraltoxicityofphrygilanthusacutifoliusflowers AT reynosomarcos antioxidantactivityandacuteoraltoxicityofphrygilanthusacutifoliusflowers AT habibnatalia antioxidantactivityandacuteoraltoxicityofphrygilanthusacutifoliusflowers AT sanchezrieraalicia antioxidantactivityandacuteoraltoxicityofphrygilanthusacutifoliusflowers |
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Repositorios |
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1764820487195590656 |