Effect of sodium tungstate on obesity induced cardiac hypertrophy and oxidative stress
Obesity was induced by high fat diet (30 % fat by weight). Wistar rats of 225-250 g were kept on high fat diet to induce obesity for 90 days. Sodium tungstate (2 mg/ml, in drinking water) was administered for 90 days. Obesity was assessed by measuring % age change in body weight, WHR ratio, adipos...
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| Autores principales: | , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7977 http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_16.pdf |
| Aporte de: |
| Sumario: | Obesity was induced by high fat diet (30 % fat by weight). Wistar rats of 225-250 g were kept
on high fat diet to induce obesity for 90 days. Sodium tungstate (2 mg/ml, in drinking water) was administered
for 90 days. Obesity was assessed by measuring % age change in body weight, WHR ratio, adiposity
index and obesity index. Left ventricular cardiac hypertrophy was assessed in terms of left ventricular
weight, left ventricular wall thickness, left ventricular protein content and left ventricular collagen content.
Oxidative stress was measured in terms of levels of thiobarbituric acid reactive substances (TBARS),
superoxide anion generation (SAG) and level of reduced glutathione. Sodium tungstate significantly attenuated
the increase in body weight adiposity index, obesity index, TBARS, SAG and reduced glutathione,
whereas no significant change was observed the parameters of cardiac hypertrophy. So, it can be concluded
that sodium tungstate significantly attenuated high fat diet induced obesity and oxidative stress but no
significant decrease was observed in the parameters of cardiac hypertrophy. |
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