Effect of sodium tungstate on obesity induced cardiac hypertrophy and oxidative stress

Obesity was induced by high fat diet (30 % fat by weight). Wistar rats of 225-250 g were kept on high fat diet to induce obesity for 90 days. Sodium tungstate (2 mg/ml, in drinking water) was administered for 90 days. Obesity was assessed by measuring % age change in body weight, WHR ratio, adipos...

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Detalles Bibliográficos
Autores principales: Singh, Randhir, Singh, Manjeet, Krishan, Pawan
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
obesity; oxidative stress; sodium tungstate
Farmacología
Sobrepeso
Análisis químico
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7977
http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_16.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7977
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
obesity; oxidative stress; sodium tungstate
Farmacología
Sobrepeso
Análisis químico
spellingShingle Farmacia
obesity; oxidative stress; sodium tungstate
Farmacología
Sobrepeso
Análisis químico
Singh, Randhir
Singh, Manjeet
Krishan, Pawan
Effect of sodium tungstate on obesity induced cardiac hypertrophy and oxidative stress
topic_facet Farmacia
obesity; oxidative stress; sodium tungstate
Farmacología
Sobrepeso
Análisis químico
description Obesity was induced by high fat diet (30 % fat by weight). Wistar rats of 225-250 g were kept on high fat diet to induce obesity for 90 days. Sodium tungstate (2 mg/ml, in drinking water) was administered for 90 days. Obesity was assessed by measuring % age change in body weight, WHR ratio, adiposity index and obesity index. Left ventricular cardiac hypertrophy was assessed in terms of left ventricular weight, left ventricular wall thickness, left ventricular protein content and left ventricular collagen content. Oxidative stress was measured in terms of levels of thiobarbituric acid reactive substances (TBARS), superoxide anion generation (SAG) and level of reduced glutathione. Sodium tungstate significantly attenuated the increase in body weight adiposity index, obesity index, TBARS, SAG and reduced glutathione, whereas no significant change was observed the parameters of cardiac hypertrophy. So, it can be concluded that sodium tungstate significantly attenuated high fat diet induced obesity and oxidative stress but no significant decrease was observed in the parameters of cardiac hypertrophy.
format Articulo
Articulo
author Singh, Randhir
Singh, Manjeet
Krishan, Pawan
author_facet Singh, Randhir
Singh, Manjeet
Krishan, Pawan
author_sort Singh, Randhir
title Effect of sodium tungstate on obesity induced cardiac hypertrophy and oxidative stress
title_short Effect of sodium tungstate on obesity induced cardiac hypertrophy and oxidative stress
title_full Effect of sodium tungstate on obesity induced cardiac hypertrophy and oxidative stress
title_fullStr Effect of sodium tungstate on obesity induced cardiac hypertrophy and oxidative stress
title_full_unstemmed Effect of sodium tungstate on obesity induced cardiac hypertrophy and oxidative stress
title_sort effect of sodium tungstate on obesity induced cardiac hypertrophy and oxidative stress
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/7977
http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_16.pdf
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AT singhmanjeet effectofsodiumtungstateonobesityinducedcardiachypertrophyandoxidativestress
AT krishanpawan effectofsodiumtungstateonobesityinducedcardiachypertrophyandoxidativestress
bdutipo_str Repositorios
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