Evaluation of biodegradable implants based on polymer blends: development, characterization and in vitro release studies

Implants prepared with polymer blends [poly (e-caprolactone)-poly(lactide), PCL-PLA] at different rates were developed from microspheres. Approximately 19% of dexamethasone acetate was encapsulated into the microspheres, and it was not dependent on polymer characteristics. DSC studies suggested t...

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Detalles Bibliográficos
Autores principales:	Fialho, Sílvia L., Prado, Laura M. F., Ferreira, Diêgo S., Pereira, Bruno G., Faraco, André A.G., Silva Cunha Júnior, Armando da
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2010
Materias:	Farmacia Farmacología biodegradable implants; in vitro study; microspheres; polymer blends In vitro Microesferas
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7970 http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_8.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-7970
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Farmacología biodegradable implants; in vitro study; microspheres; polymer blends In vitro Microesferas
spellingShingle	Farmacia Farmacología biodegradable implants; in vitro study; microspheres; polymer blends In vitro Microesferas Fialho, Sílvia L. Prado, Laura M. F. Ferreira, Diêgo S. Pereira, Bruno G. Faraco, André A.G. Silva Cunha Júnior, Armando da Evaluation of biodegradable implants based on polymer blends: development, characterization and in vitro release studies
topic_facet	Farmacia Farmacología biodegradable implants; in vitro study; microspheres; polymer blends In vitro Microesferas
description	Implants prepared with polymer blends [poly (e-caprolactone)-poly(lactide), PCL-PLA] at different rates were developed from microspheres. Approximately 19% of dexamethasone acetate was encapsulated into the microspheres, and it was not dependent on polymer characteristics. DSC studies suggested that there is not any signal of interaction between the polymers and the drug and also no influence of any residual solvent in the microspheres. Infrared analysis indicated the chemical stability of the drug even in the blend matrix. The developed devices present low degradation rate. 34% and 21% of dexamethasone acetate was released from PLA and PCL alone implants at 10 weeks, respectively. Intermediate amounts were released from the devices prepared at different PLA-PCL ratios in such a way that the higher the amount of PCL, the slower was the drug release. This study demonstrates that polymeric drug delivery systems allowed to a prolonged release of dexamethasone acetate in vitro.
format	Articulo Articulo
author	Fialho, Sílvia L. Prado, Laura M. F. Ferreira, Diêgo S. Pereira, Bruno G. Faraco, André A.G. Silva Cunha Júnior, Armando da
author_facet	Fialho, Sílvia L. Prado, Laura M. F. Ferreira, Diêgo S. Pereira, Bruno G. Faraco, André A.G. Silva Cunha Júnior, Armando da
author_sort	Fialho, Sílvia L.
title	Evaluation of biodegradable implants based on polymer blends: development, characterization and in vitro release studies
title_short	Evaluation of biodegradable implants based on polymer blends: development, characterization and in vitro release studies
title_full	Evaluation of biodegradable implants based on polymer blends: development, characterization and in vitro release studies
title_fullStr	Evaluation of biodegradable implants based on polymer blends: development, characterization and in vitro release studies
title_full_unstemmed	Evaluation of biodegradable implants based on polymer blends: development, characterization and in vitro release studies
title_sort	evaluation of biodegradable implants based on polymer blends: development, characterization and in vitro release studies
publishDate	2010
url	http://sedici.unlp.edu.ar/handle/10915/7970 http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_8.pdf
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Evaluation of biodegradable implants based on polymer blends: development, characterization and in vitro release studies

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