Fast dispersible tablet of paroxetine hydrochloride: taste masking and administration in depressed patients
The bitter taste of paroxetine hydrochloride was masked by complexation with beta cyclodextrin. Complexation of paroxetine hydrochloride with beta cyclodextrin was characterized by differential scanning calorimetry and X-ray powder diffraction. The taste masked complex was directly compressed int...
| Autores principales: | , |
|---|---|
| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7966 http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_4.pdf |
| Aporte de: |
| id |
I19-R120-10915-7966 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Farmacología B-cyclodextrin; depression; paroxetine; tablets; taste masking Evaluación de drogas |
| spellingShingle |
Farmacia Farmacología B-cyclodextrin; depression; paroxetine; tablets; taste masking Evaluación de drogas Syed, Moinuddin R. Naik, Jitendra B. Fast dispersible tablet of paroxetine hydrochloride: taste masking and administration in depressed patients |
| topic_facet |
Farmacia Farmacología B-cyclodextrin; depression; paroxetine; tablets; taste masking Evaluación de drogas |
| description |
The bitter taste of paroxetine hydrochloride was masked by complexation with beta cyclodextrin.
Complexation of paroxetine hydrochloride with beta cyclodextrin was characterized by differential
scanning calorimetry and X-ray powder diffraction. The taste masked complex was directly compressed
into tablets using povidone Cl as a super-disintegrant along with other excipients which aid in further
improvement of taste. The prepared tablets containing the taste masked complex were evaluated for
taste by both in vitro release profile and through panel testing. The taste masked tablets were administered
to actual patients by mixing with juices to study weather the patients identifies the presence of medicine in
the juices. The results of this study were satisfactory. |
| format |
Articulo Articulo |
| author |
Syed, Moinuddin R. Naik, Jitendra B. |
| author_facet |
Syed, Moinuddin R. Naik, Jitendra B. |
| author_sort |
Syed, Moinuddin R. |
| title |
Fast dispersible tablet of paroxetine hydrochloride: taste masking and administration in depressed patients |
| title_short |
Fast dispersible tablet of paroxetine hydrochloride: taste masking and administration in depressed patients |
| title_full |
Fast dispersible tablet of paroxetine hydrochloride: taste masking and administration in depressed patients |
| title_fullStr |
Fast dispersible tablet of paroxetine hydrochloride: taste masking and administration in depressed patients |
| title_full_unstemmed |
Fast dispersible tablet of paroxetine hydrochloride: taste masking and administration in depressed patients |
| title_sort |
fast dispersible tablet of paroxetine hydrochloride: taste masking and administration in depressed patients |
| publishDate |
2010 |
| url |
http://sedici.unlp.edu.ar/handle/10915/7966 http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_4.pdf |
| work_keys_str_mv |
AT syedmoinuddinr fastdispersibletabletofparoxetinehydrochloridetastemaskingandadministrationindepressedpatients AT naikjitendrab fastdispersibletabletofparoxetinehydrochloridetastemaskingandadministrationindepressedpatients |
| bdutipo_str |
Repositorios |
| _version_ |
1764820486989021184 |