Irbesartan loaded self emulsifying drug delivery system: pseudoternary phase diagram, formulation, characterization and in vitro dissolution studies

A self-emulsifying drug delivery system (SEDDS) of a poorly water soluble drug, irbesartan (IRB), was designed. The aim was to improve the solubility as well as dissolution rates of IRB. Solubility of IRB in different vehicles were determined and a pseudoternary phase diagram was constructed as pr...

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Detalles Bibliográficos
Autores principales: Haque, Tasnuva, Talukder, Mesbah U., Das, Shaikat K., Laila, Susmita
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
dissolution studies; irbesartan; pseudoternary phase diagram; SEDDS
Medicamentos
Farmacología
Solubilidad
Disolución
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7964
http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_9.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7964
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
dissolution studies; irbesartan; pseudoternary phase diagram; SEDDS
Medicamentos
Farmacología
Solubilidad
Disolución
spellingShingle Farmacia
dissolution studies; irbesartan; pseudoternary phase diagram; SEDDS
Medicamentos
Farmacología
Solubilidad
Disolución
Haque, Tasnuva
Talukder, Mesbah U.
Das, Shaikat K.
Laila, Susmita
Irbesartan loaded self emulsifying drug delivery system: pseudoternary phase diagram, formulation, characterization and in vitro dissolution studies
topic_facet Farmacia
dissolution studies; irbesartan; pseudoternary phase diagram; SEDDS
Medicamentos
Farmacología
Solubilidad
Disolución
description A self-emulsifying drug delivery system (SEDDS) of a poorly water soluble drug, irbesartan (IRB), was designed. The aim was to improve the solubility as well as dissolution rates of IRB. Solubility of IRB in different vehicles were determined and a pseudoternary phase diagram was constructed as preliminary studies to formulate SEDDS. From the pseudoternary plot it was observed that the microemulsion existence area increased as the surfactant-cosurfactant ratio (Smix) increased and increasing the surfactant ratio, loss of flowability was observed. Smix of 3:1 and 4:1 were selected for formulating SEDDS. After formulation emulsification, dispersibility test and thermodynamic stability studies were performed. From dissolution results, it was observed that increasing oil-surfactant ratio, the rate of dissolution of IRB was decreased and the dissolution rate was increased with the increasing the Smix ratio. Dispersibilty test showed that most of the formulations falls within the grade B. Least emulsification time was found for F-1 and all the formulations were found to be thermodynamically stable with slightly deviations.
format Articulo
Articulo
author Haque, Tasnuva
Talukder, Mesbah U.
Das, Shaikat K.
Laila, Susmita
author_facet Haque, Tasnuva
Talukder, Mesbah U.
Das, Shaikat K.
Laila, Susmita
author_sort Haque, Tasnuva
title Irbesartan loaded self emulsifying drug delivery system: pseudoternary phase diagram, formulation, characterization and in vitro dissolution studies
title_short Irbesartan loaded self emulsifying drug delivery system: pseudoternary phase diagram, formulation, characterization and in vitro dissolution studies
title_full Irbesartan loaded self emulsifying drug delivery system: pseudoternary phase diagram, formulation, characterization and in vitro dissolution studies
title_fullStr Irbesartan loaded self emulsifying drug delivery system: pseudoternary phase diagram, formulation, characterization and in vitro dissolution studies
title_full_unstemmed Irbesartan loaded self emulsifying drug delivery system: pseudoternary phase diagram, formulation, characterization and in vitro dissolution studies
title_sort irbesartan loaded self emulsifying drug delivery system: pseudoternary phase diagram, formulation, characterization and in vitro dissolution studies
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/7964
http://www.latamjpharm.org/resumenes/29/5/LAJOP_29_5_1_9.pdf
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AT dasshaikatk irbesartanloadedselfemulsifyingdrugdeliverysystempseudoternaryphasediagramformulationcharacterizationandinvitrodissolutionstudies
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bdutipo_str Repositorios
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