Antiglycation, antiplatelets aggregation, cytotoxic and phytotoxic activities of Nepeta suavis

Nepeta suavis Stapf. (Lamiaceae), one of the ignored species for testing biological activities, was studied. In present research, the Nepeta suavis fractions: chloroform (FC), ethyl acetate (FE) and aqueous (FW) were evaluated for platelet aggregation, antiglycation, cytoxicity, and phytotoxicity. F...

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Detalles Bibliográficos
Autores principales:	Hussain, Javid, Khan, Farman-ullah, Gilani, Syed A., Abbas, Ghulam, Ahmed, Sagheer, Khan, Arif-ullah, Ullah, Wasi, Choudhary, Muhammad I.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2010
Materias:	Farmacia antiglycation; antiplatelets; cytotoxic; phytotoxicity Farmacología Citotoxicidad
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7950 http://www.latamjpharm.org/resumenes/29/4/LAJOP_29_4_1_13.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-7950
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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia antiglycation; antiplatelets; cytotoxic; phytotoxicity Farmacología Citotoxicidad
spellingShingle	Farmacia antiglycation; antiplatelets; cytotoxic; phytotoxicity Farmacología Citotoxicidad Hussain, Javid Khan, Farman-ullah Gilani, Syed A. Abbas, Ghulam Ahmed, Sagheer Khan, Arif-ullah Ullah, Wasi Choudhary, Muhammad I. Antiglycation, antiplatelets aggregation, cytotoxic and phytotoxic activities of Nepeta suavis
topic_facet	Farmacia antiglycation; antiplatelets; cytotoxic; phytotoxicity Farmacología Citotoxicidad
description	Nepeta suavis Stapf. (Lamiaceae), one of the ignored species for testing biological activities, was studied. In present research, the Nepeta suavis fractions: chloroform (FC), ethyl acetate (FE) and aqueous (FW) were evaluated for platelet aggregation, antiglycation, cytoxicity, and phytotoxicity. FE showed 65.60% antiglycation activity against the protein glycation while the other fractions showed less than 50% inhibitory potential. The FW inhibited arachidonic acid (AA) and platelet activating factor (acetyl-glyceryl-ether-phosphorylcholine, PAF) induced platelet aggregation. FE showed significant cytotoxicity against brine shrimp larvae with LD50 of 41.3 μg/ml. Phytotoxic studies of FC, FE and FW against Lemna minor showed 77.5-100% inhibitory effects at 1000 μg/ml. However, at lower concentration (10 μg/ml) enhancing effects were observed in FC and FE, as compared to control. FW remained in a uniform pattern of inhibitory effects in all three concentrations (10,100 and 1000 μg/ml). FE showed highest inhibitory activities against formation of glycation, while FW showed significant inhibitory effects against platelet aggregation and Lemna minor. Both of these fractions are recommended for further study to identify and isolate active chemical compounds.
format	Articulo Articulo
author	Hussain, Javid Khan, Farman-ullah Gilani, Syed A. Abbas, Ghulam Ahmed, Sagheer Khan, Arif-ullah Ullah, Wasi Choudhary, Muhammad I.
author_facet	Hussain, Javid Khan, Farman-ullah Gilani, Syed A. Abbas, Ghulam Ahmed, Sagheer Khan, Arif-ullah Ullah, Wasi Choudhary, Muhammad I.
author_sort	Hussain, Javid
title	Antiglycation, antiplatelets aggregation, cytotoxic and phytotoxic activities of Nepeta suavis
title_short	Antiglycation, antiplatelets aggregation, cytotoxic and phytotoxic activities of Nepeta suavis
title_full	Antiglycation, antiplatelets aggregation, cytotoxic and phytotoxic activities of Nepeta suavis
title_fullStr	Antiglycation, antiplatelets aggregation, cytotoxic and phytotoxic activities of Nepeta suavis
title_full_unstemmed	Antiglycation, antiplatelets aggregation, cytotoxic and phytotoxic activities of Nepeta suavis
title_sort	antiglycation, antiplatelets aggregation, cytotoxic and phytotoxic activities of nepeta suavis
publishDate	2010
url	http://sedici.unlp.edu.ar/handle/10915/7950 http://www.latamjpharm.org/resumenes/29/4/LAJOP_29_4_1_13.pdf
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bdutipo_str	Repositorios
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Antiglycation, antiplatelets aggregation, cytotoxic and phytotoxic activities of Nepeta suavis

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