Study of nimesulide release from ethylcellulose microparticles and drug-polymer compatibility analysis

The aim of this study was to formulate ethyl cellulose (EC) microparticles for sustained release of nimesulide and study the effect of processing variables, drug to polymer ratio and also study the drug polymer compatibility. The microparticles were prepared by coacervation (temperature change) tech...

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Detalles Bibliográficos
Autores principales: Khan, Shujaat A., Ahmad, Mahmood, Aamir, Muhammad N., Murtaza, Ghulam, Rasool, Fatima, Akhtar, Muhammad
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
ethyl cellulose; microparticles; nimesulide; polymer ratio; processing variables
Farmacología
Medicamentos
Polímeros
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7947
http://www.latamjpharm.org/resumenes/29/4/LAJOP_29_4_1_10.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7947
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
ethyl cellulose; microparticles; nimesulide; polymer ratio; processing variables
Farmacología
Medicamentos
Polímeros
spellingShingle Farmacia
ethyl cellulose; microparticles; nimesulide; polymer ratio; processing variables
Farmacología
Medicamentos
Polímeros
Khan, Shujaat A.
Ahmad, Mahmood
Aamir, Muhammad N.
Murtaza, Ghulam
Rasool, Fatima
Akhtar, Muhammad
Study of nimesulide release from ethylcellulose microparticles and drug-polymer compatibility analysis
topic_facet Farmacia
ethyl cellulose; microparticles; nimesulide; polymer ratio; processing variables
Farmacología
Medicamentos
Polímeros
description The aim of this study was to formulate ethyl cellulose (EC) microparticles for sustained release of nimesulide and study the effect of processing variables, drug to polymer ratio and also study the drug polymer compatibility. The microparticles were prepared by coacervation (temperature change) technique. Physical properties, such as particle size, entrapment efficiency, release pattern and morphological characteristics were investigated by in vitro dissolution, SEM, FTIR, XRD, DSC and TGA in order to optimize the formulation of the microparticles. With the increase of polymer concentration there was an increase in size and drug entrapment efficiency of microparticles. There was a decrease in size and nonlinear change in entrapment efficiency with the increase of stirring speed and time. The release of drug from microparticles was anomalous diffusion. It was confirmed that there is no strong chemical interaction between drug and polymer except the change in crystal habit and polymorphism. Ethyl cellulose microparticles containing nimesulide are suitable for controlled release devising.
format Articulo
Articulo
author Khan, Shujaat A.
Ahmad, Mahmood
Aamir, Muhammad N.
Murtaza, Ghulam
Rasool, Fatima
Akhtar, Muhammad
author_facet Khan, Shujaat A.
Ahmad, Mahmood
Aamir, Muhammad N.
Murtaza, Ghulam
Rasool, Fatima
Akhtar, Muhammad
author_sort Khan, Shujaat A.
title Study of nimesulide release from ethylcellulose microparticles and drug-polymer compatibility analysis
title_short Study of nimesulide release from ethylcellulose microparticles and drug-polymer compatibility analysis
title_full Study of nimesulide release from ethylcellulose microparticles and drug-polymer compatibility analysis
title_fullStr Study of nimesulide release from ethylcellulose microparticles and drug-polymer compatibility analysis
title_full_unstemmed Study of nimesulide release from ethylcellulose microparticles and drug-polymer compatibility analysis
title_sort study of nimesulide release from ethylcellulose microparticles and drug-polymer compatibility analysis
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/7947
http://www.latamjpharm.org/resumenes/29/4/LAJOP_29_4_1_10.pdf
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bdutipo_str Repositorios
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