Analgesic and neuropharmacological effects of Xanthium indicum leaves

The present study investigated analgesic and some neuropharmacological effects of hydromethanolic extract of the leaves of Xanthium indicum Koenig in mice models. The analgesic activity was evaluated using hot plate ant tail immersion methods, and acetic acid-induced writhing test. The neuropharmaco...

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Autores principales:	Akter, Raushanara, Hasan, Raquibul, Hossain, Mokarram, Jamila, Mariam, Mazumder, Mohammed Ehsanul H., Rana, Sohel, Rahman, Shafiqur
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2010
Materias:	Farmacia Xanthium indicum; analgesic activity; neuropharmacological effects; medicinal plant Farmacología Extractos de plantas Plantas medicinales
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7942 http://www.latamjpharm.org/resumenes/29/4/LAJOP_29_4_1_5.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Xanthium indicum; analgesic activity; neuropharmacological effects; medicinal plant Farmacología Extractos de plantas Plantas medicinales
spellingShingle	Farmacia Xanthium indicum; analgesic activity; neuropharmacological effects; medicinal plant Farmacología Extractos de plantas Plantas medicinales Akter, Raushanara Hasan, Raquibul Hossain, Mokarram Jamila, Mariam Mazumder, Mohammed Ehsanul H. Rana, Sohel Rahman, Shafiqur Analgesic and neuropharmacological effects of Xanthium indicum leaves
topic_facet	Farmacia Xanthium indicum; analgesic activity; neuropharmacological effects; medicinal plant Farmacología Extractos de plantas Plantas medicinales
description	The present study investigated analgesic and some neuropharmacological effects of hydromethanolic extract of the leaves of Xanthium indicum Koenig in mice models. The analgesic activity was evaluated using hot plate ant tail immersion methods, and acetic acid-induced writhing test. The neuropharmacological effects were determined using hole-cross, open field, and thiopental-induced sleeping time tests. The extract, at the doses of 100, 200 and 400 mg/kg, produced a dose dependent and significant (p < 0.05-0.001) increase in pain threshold in hotplate test. However, in tail immersion method, the extract at 200 and 400 mg/kg dose levels displayed a significant (p < 0.05-0.001) increase in tail withdrawal reflex in a dose dependent manner. In either case, maximum analgesia was observed at 90 min after administration of test drugs and the standard drug Nalbuphine. In acetic acid-induced writhing test, the extract at all doses produced a significant (p <0.001) decrease in the number of writhes exhibited by the mice following intraperitoneal injection of acetic acid; the result was dose dependent and comparable to the reference drug Diclofenac-Na. Moreover, The extract displayed dose dependent suppression of locomotor activity as well as exploratory behavior in hole-cross and open field tests, and exerted sedative action through prolongation of thiopental-induced sleeping time. The results of the study supports that the Xanthium indicum leaves possesses analgesic and some neuropharmacological effects which might be linked to inhibition of both central and peripheral mechanisms of pain and justifies its use in folk medicine for the management of pain and inflammation.
format	Articulo Articulo
author	Akter, Raushanara Hasan, Raquibul Hossain, Mokarram Jamila, Mariam Mazumder, Mohammed Ehsanul H. Rana, Sohel Rahman, Shafiqur
author_facet	Akter, Raushanara Hasan, Raquibul Hossain, Mokarram Jamila, Mariam Mazumder, Mohammed Ehsanul H. Rana, Sohel Rahman, Shafiqur
author_sort	Akter, Raushanara
title	Analgesic and neuropharmacological effects of Xanthium indicum leaves
title_short	Analgesic and neuropharmacological effects of Xanthium indicum leaves
title_full	Analgesic and neuropharmacological effects of Xanthium indicum leaves
title_fullStr	Analgesic and neuropharmacological effects of Xanthium indicum leaves
title_full_unstemmed	Analgesic and neuropharmacological effects of Xanthium indicum leaves
title_sort	analgesic and neuropharmacological effects of xanthium indicum leaves
publishDate	2010
url	http://sedici.unlp.edu.ar/handle/10915/7942 http://www.latamjpharm.org/resumenes/29/4/LAJOP_29_4_1_5.pdf
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bdutipo_str	Repositorios
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Analgesic and neuropharmacological effects of Xanthium indicum leaves

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