Bioavailability enhancement of sulpiride by self-microemulsifying drug delivery system

The self-microemulsifying drug delivery system (SMEDDS) was employed to improve the bioavailability of sulpiride, a drug which is poorly soluble. The mean droplet size and emulsification time of the test formulation used for in vivo study were 9.27 ± 2.02 nm and 87 ± 5 s, respectively. When compar...

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Detalles Bibliográficos
Autores principales: Chitneni, Mallikarjun, Janagama, Srujana, Khiang, Peh K., Yusrida, Darwis
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
self-microemulsifying drug delivery system; sulpiride; bioavailability
Farmacología
Medicamentos
Disponibilidad biológica
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7941
http://www.latamjpharm.org/resumenes/29/4/LAJOP_29_4_1_4.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7941
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
self-microemulsifying drug delivery system; sulpiride; bioavailability
Farmacología
Medicamentos
Disponibilidad biológica
spellingShingle Farmacia
self-microemulsifying drug delivery system; sulpiride; bioavailability
Farmacología
Medicamentos
Disponibilidad biológica
Chitneni, Mallikarjun
Janagama, Srujana
Khiang, Peh K.
Yusrida, Darwis
Bioavailability enhancement of sulpiride by self-microemulsifying drug delivery system
topic_facet Farmacia
self-microemulsifying drug delivery system; sulpiride; bioavailability
Farmacología
Medicamentos
Disponibilidad biológica
description The self-microemulsifying drug delivery system (SMEDDS) was employed to improve the bioavailability of sulpiride, a drug which is poorly soluble. The mean droplet size and emulsification time of the test formulation used for in vivo study were 9.27 ± 2.02 nm and 87 ± 5 s, respectively. When compared with Reference (Dogmatil®), the test formulation exhibited faster in-vitro drug release rate. The Cmax and AUC values of the test formulation were significantly higher than those of Reference, with an enhancement of 210.64% in the extent of absorption in rabbits. In conclusion, SMEDDS could be a potential drug delivery system to enhance the bioavailability of sulpiride.
format Articulo
Articulo
author Chitneni, Mallikarjun
Janagama, Srujana
Khiang, Peh K.
Yusrida, Darwis
author_facet Chitneni, Mallikarjun
Janagama, Srujana
Khiang, Peh K.
Yusrida, Darwis
author_sort Chitneni, Mallikarjun
title Bioavailability enhancement of sulpiride by self-microemulsifying drug delivery system
title_short Bioavailability enhancement of sulpiride by self-microemulsifying drug delivery system
title_full Bioavailability enhancement of sulpiride by self-microemulsifying drug delivery system
title_fullStr Bioavailability enhancement of sulpiride by self-microemulsifying drug delivery system
title_full_unstemmed Bioavailability enhancement of sulpiride by self-microemulsifying drug delivery system
title_sort bioavailability enhancement of sulpiride by self-microemulsifying drug delivery system
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/7941
http://www.latamjpharm.org/resumenes/29/4/LAJOP_29_4_1_4.pdf
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AT janagamasrujana bioavailabilityenhancementofsulpiridebyselfmicroemulsifyingdrugdeliverysystem
AT khiangpehk bioavailabilityenhancementofsulpiridebyselfmicroemulsifyingdrugdeliverysystem
AT yusridadarwis bioavailabilityenhancementofsulpiridebyselfmicroemulsifyingdrugdeliverysystem
bdutipo_str Repositorios
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