Drug excipient interaction study with polymorphic forms of tibolone.

Powder mixtures (1:1) of tibolone polymorphic forms I (monoclinic) and II (triclinic) and excipients have been prepared and compacted. The samples were stored at 50 °C and 90% RH for one month and subsequently were evaluated using differential scanning calorimetry (DSC) and high-performance liquid...

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Detalles Bibliográficos
Autores principales: Araujo, Gabriel L. B., Salvio Neto, Helio, Zaim, Márcio H., Matos, Jivaldo R.
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
Farmacología
Drug-excipient interaction; polymorphism of drugs; solid-state characterization; thermal analysis
Estabilidad de la droga
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7936
http://www.latamjpharm.org/resumenes/29/3/LAJOP_29_3_2_6.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7936
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Farmacología
Drug-excipient interaction; polymorphism of drugs; solid-state characterization; thermal analysis
Estabilidad de la droga
spellingShingle Farmacia
Farmacología
Drug-excipient interaction; polymorphism of drugs; solid-state characterization; thermal analysis
Estabilidad de la droga
Araujo, Gabriel L. B.
Salvio Neto, Helio
Zaim, Márcio H.
Matos, Jivaldo R.
Drug excipient interaction study with polymorphic forms of tibolone.
topic_facet Farmacia
Farmacología
Drug-excipient interaction; polymorphism of drugs; solid-state characterization; thermal analysis
Estabilidad de la droga
description Powder mixtures (1:1) of tibolone polymorphic forms I (monoclinic) and II (triclinic) and excipients have been prepared and compacted. The samples were stored at 50 °C and 90% RH for one month and subsequently were evaluated using differential scanning calorimetry (DSC) and high-performance liquid chromatography (HPLC). The results indicate that during the compaction, the applied pressure reduced the chemical stability of tibolone in both polymorph forms. The triclinic form was more chemically unstable, both pure and in contact with excipients, than the monoclinic form. Lactose monohydrate was shown to reduce chemical degradation for both forms. Ascorbyl palmitate was shown to affect the tibolone stability differently depending on the polymorphic form used.
format Articulo
Comunicacion
author Araujo, Gabriel L. B.
Salvio Neto, Helio
Zaim, Márcio H.
Matos, Jivaldo R.
author_facet Araujo, Gabriel L. B.
Salvio Neto, Helio
Zaim, Márcio H.
Matos, Jivaldo R.
author_sort Araujo, Gabriel L. B.
title Drug excipient interaction study with polymorphic forms of tibolone.
title_short Drug excipient interaction study with polymorphic forms of tibolone.
title_full Drug excipient interaction study with polymorphic forms of tibolone.
title_fullStr Drug excipient interaction study with polymorphic forms of tibolone.
title_full_unstemmed Drug excipient interaction study with polymorphic forms of tibolone.
title_sort drug excipient interaction study with polymorphic forms of tibolone.
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/7936
http://www.latamjpharm.org/resumenes/29/3/LAJOP_29_3_2_6.pdf
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