Comparative Study on the Pharmacokinetics of Rutin and Quercetin in Diabetic and Normal Rats by HPLC-DAD
Diabetes mellitus (DM) is a serious health problem affecting millions of individuals worldwide. It is showed that some changes of many enzymes and transporters concerned with metabolism and disposal of drug have taken place in organism under pathologic state of DM. The pharmacokinetic of drug sho...
Guardado en:
Autores principales: | , , , , , |
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Formato: | Articulo |
Lenguaje: | Inglés |
Publicado: |
2010
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Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7925 http://www.latamjpharm.org/resumenes/29/3/LAJOP_29_3_1_12.pdf |
Aporte de: |
id |
I19-R120-10915-7925 |
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record_format |
dspace |
institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Farmacia Farmacología diabetes mellitus; high performance liquid chromatography; pharmacokinetic; rutin; Quercetin Diabetes Mellitus Farmacocinética |
spellingShingle |
Farmacia Farmacología diabetes mellitus; high performance liquid chromatography; pharmacokinetic; rutin; Quercetin Diabetes Mellitus Farmacocinética Tang, Daoquan Gao, Yuanyuan Tang, Anbang Chen, Yonggang Wei, Yaqin Yin, Xiaoxin Comparative Study on the Pharmacokinetics of Rutin and Quercetin in Diabetic and Normal Rats by HPLC-DAD |
topic_facet |
Farmacia Farmacología diabetes mellitus; high performance liquid chromatography; pharmacokinetic; rutin; Quercetin Diabetes Mellitus Farmacocinética |
description |
Diabetes mellitus (DM) is a serious health problem affecting millions of individuals worldwide.
It is showed that some changes of many enzymes and transporters concerned with metabolism and
disposal of drug have taken place in organism under pathologic state of DM. The pharmacokinetic of drug
should be different between diabetic and normal animals. Rutin and quercetin can also be used to treatment
of diabetic mellitus. So, this paper investigated the difference of pharmacokinetic profiles of rutin
and quercetin in diabetic and normal rats in vivo by HPLC-DAD method. The pharmacokinetic parameters
were analyzed by double-compartmental method (DAS2.0). The pharmacokinetic parameters of rutin
in normal and diabetic rats were: (22.203 ± 2.6) and (36.174 ± 7.5) mg · h/L for AUC(0-4); (0.726 ± 0.13)
and (1.069 ± 0.17) h for MRT(0-4), (5.413 ± 0.57) and (6.595 ± 0.38) h for t1/2; (0.424 ± 0.071) and (0.226 ±
0.072) L/h/kg for Cl, respectively. The pharmacokinetic parameters of quercetin in normal and diabetic
rats were: (5.243 ± 0.82) and (2.376 ± 0.61) mg h/L for AUC(0-4); (2.556 ± 0.52) and (1.616 ± 0.35) h for
MRT(0-4), (1.216 ± 0.17) and (0.992 ± 0.12) h for t1/2; (1.918 ± 0.32) and (4.342 ± 0.99) L/h/kg for Cl, respectively.
Those results indicate that the pharmacokinetic profiles of rutin and quercetin were changed by
DM. |
format |
Articulo Articulo |
author |
Tang, Daoquan Gao, Yuanyuan Tang, Anbang Chen, Yonggang Wei, Yaqin Yin, Xiaoxin |
author_facet |
Tang, Daoquan Gao, Yuanyuan Tang, Anbang Chen, Yonggang Wei, Yaqin Yin, Xiaoxin |
author_sort |
Tang, Daoquan |
title |
Comparative Study on the Pharmacokinetics of Rutin and Quercetin in Diabetic and Normal Rats by HPLC-DAD |
title_short |
Comparative Study on the Pharmacokinetics of Rutin and Quercetin in Diabetic and Normal Rats by HPLC-DAD |
title_full |
Comparative Study on the Pharmacokinetics of Rutin and Quercetin in Diabetic and Normal Rats by HPLC-DAD |
title_fullStr |
Comparative Study on the Pharmacokinetics of Rutin and Quercetin in Diabetic and Normal Rats by HPLC-DAD |
title_full_unstemmed |
Comparative Study on the Pharmacokinetics of Rutin and Quercetin in Diabetic and Normal Rats by HPLC-DAD |
title_sort |
comparative study on the pharmacokinetics of rutin and quercetin in diabetic and normal rats by hplc-dad |
publishDate |
2010 |
url |
http://sedici.unlp.edu.ar/handle/10915/7925 http://www.latamjpharm.org/resumenes/29/3/LAJOP_29_3_1_12.pdf |
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bdutipo_str |
Repositorios |
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1764820486433275904 |