Comparative Study on the Pharmacokinetics of Rutin and Quercetin in Diabetic and Normal Rats by HPLC-DAD

Diabetes mellitus (DM) is a serious health problem affecting millions of individuals worldwide. It is showed that some changes of many enzymes and transporters concerned with metabolism and disposal of drug have taken place in organism under pathologic state of DM. The pharmacokinetic of drug sho...

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Autores principales: Tang, Daoquan, Gao, Yuanyuan, Tang, Anbang, Chen, Yonggang, Wei, Yaqin, Yin, Xiaoxin
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7925
http://www.latamjpharm.org/resumenes/29/3/LAJOP_29_3_1_12.pdf
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id I19-R120-10915-7925
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Farmacología
diabetes mellitus; high performance liquid chromatography; pharmacokinetic; rutin; Quercetin
Diabetes Mellitus
Farmacocinética
spellingShingle Farmacia
Farmacología
diabetes mellitus; high performance liquid chromatography; pharmacokinetic; rutin; Quercetin
Diabetes Mellitus
Farmacocinética
Tang, Daoquan
Gao, Yuanyuan
Tang, Anbang
Chen, Yonggang
Wei, Yaqin
Yin, Xiaoxin
Comparative Study on the Pharmacokinetics of Rutin and Quercetin in Diabetic and Normal Rats by HPLC-DAD
topic_facet Farmacia
Farmacología
diabetes mellitus; high performance liquid chromatography; pharmacokinetic; rutin; Quercetin
Diabetes Mellitus
Farmacocinética
description Diabetes mellitus (DM) is a serious health problem affecting millions of individuals worldwide. It is showed that some changes of many enzymes and transporters concerned with metabolism and disposal of drug have taken place in organism under pathologic state of DM. The pharmacokinetic of drug should be different between diabetic and normal animals. Rutin and quercetin can also be used to treatment of diabetic mellitus. So, this paper investigated the difference of pharmacokinetic profiles of rutin and quercetin in diabetic and normal rats in vivo by HPLC-DAD method. The pharmacokinetic parameters were analyzed by double-compartmental method (DAS2.0). The pharmacokinetic parameters of rutin in normal and diabetic rats were: (22.203 ± 2.6) and (36.174 ± 7.5) mg · h/L for AUC(0-4); (0.726 ± 0.13) and (1.069 ± 0.17) h for MRT(0-4), (5.413 ± 0.57) and (6.595 ± 0.38) h for t1/2; (0.424 ± 0.071) and (0.226 ± 0.072) L/h/kg for Cl, respectively. The pharmacokinetic parameters of quercetin in normal and diabetic rats were: (5.243 ± 0.82) and (2.376 ± 0.61) mg h/L for AUC(0-4); (2.556 ± 0.52) and (1.616 ± 0.35) h for MRT(0-4), (1.216 ± 0.17) and (0.992 ± 0.12) h for t1/2; (1.918 ± 0.32) and (4.342 ± 0.99) L/h/kg for Cl, respectively. Those results indicate that the pharmacokinetic profiles of rutin and quercetin were changed by DM.
format Articulo
Articulo
author Tang, Daoquan
Gao, Yuanyuan
Tang, Anbang
Chen, Yonggang
Wei, Yaqin
Yin, Xiaoxin
author_facet Tang, Daoquan
Gao, Yuanyuan
Tang, Anbang
Chen, Yonggang
Wei, Yaqin
Yin, Xiaoxin
author_sort Tang, Daoquan
title Comparative Study on the Pharmacokinetics of Rutin and Quercetin in Diabetic and Normal Rats by HPLC-DAD
title_short Comparative Study on the Pharmacokinetics of Rutin and Quercetin in Diabetic and Normal Rats by HPLC-DAD
title_full Comparative Study on the Pharmacokinetics of Rutin and Quercetin in Diabetic and Normal Rats by HPLC-DAD
title_fullStr Comparative Study on the Pharmacokinetics of Rutin and Quercetin in Diabetic and Normal Rats by HPLC-DAD
title_full_unstemmed Comparative Study on the Pharmacokinetics of Rutin and Quercetin in Diabetic and Normal Rats by HPLC-DAD
title_sort comparative study on the pharmacokinetics of rutin and quercetin in diabetic and normal rats by hplc-dad
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/7925
http://www.latamjpharm.org/resumenes/29/3/LAJOP_29_3_1_12.pdf
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