Formulation and evaluation of thermoreversible mucoadhesive nasal gels of metoclopramide hydrochloride

The prolonged residence of drug formulation in the nasal cavity is of utmost importance for intranasal drug delivery. The objective of the present investigation was to develop a mucoadhesive in situ gel with reduced nasal mucocilliary clearance in order to improve the bioavailability of the antiemet...

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Autores principales:	Dias, Remeth J., Mali, Kailas K., Shinde, Jitendra V., Havaldar, Vijay D., Mali, Rahul K.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2010
Materias:	Farmacia metoclopramide hydrochloride; mucoadhesive; nasal drug delivery; pluronic F 127; PEG 6000 Farmacología Evaluación de medicamentos
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7918 http://www.latamjpharm.org/resumenes/29/3/LAJOP_29_3_1_5.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-7918
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia metoclopramide hydrochloride; mucoadhesive; nasal drug delivery; pluronic F 127; PEG 6000 Farmacología Evaluación de medicamentos
spellingShingle	Farmacia metoclopramide hydrochloride; mucoadhesive; nasal drug delivery; pluronic F 127; PEG 6000 Farmacología Evaluación de medicamentos Dias, Remeth J. Mali, Kailas K. Shinde, Jitendra V. Havaldar, Vijay D. Mali, Rahul K. Formulation and evaluation of thermoreversible mucoadhesive nasal gels of metoclopramide hydrochloride
topic_facet	Farmacia metoclopramide hydrochloride; mucoadhesive; nasal drug delivery; pluronic F 127; PEG 6000 Farmacología Evaluación de medicamentos
description	The prolonged residence of drug formulation in the nasal cavity is of utmost importance for intranasal drug delivery. The objective of the present investigation was to develop a mucoadhesive in situ gel with reduced nasal mucocilliary clearance in order to improve the bioavailability of the antiemetic drug, metoclopramide hydrochloride. The in situ gelation upon contact with nasal mucosa was conferred via the use of the thermogelling Pluronic flake 127 (18%). Mucoadhesion was modulated via the use of hydroxy propyl methyl cellulose (HPMC), sodium carboxy methyl cellulose (Na CMC) and sodium alginate (Na-alginate) whereas drug release was modified by varying concentrations of polyethylene glycol 6000 (PEG 6000). The results revealed that the different mucoadhesives increased the gel viscosity but reduced its sol gel transition temperatures. The increase in viscosity was highest in formulations with Na-alginate and lowest in formulations with HPMC. PEG 6000 significantly decreased mucoadhesive strength of formula containing 0.3% HPMC (776.6 ± 19.55 to 713.6 ± 5.03), 0.2% Na CMC (656 ± 11.13 to 575 ± 9.07) and 0.2% Na-alginate (659 ± 11.13 to 618.3 ± 9.45) whereas the gelation temperature increased by 3 to 4 °C. 100% of drug diffusion was found at four hours for formulation F5, F9, and F12. Formulation F5 showed maximum permeability (0.00949 ± 0.00021 mg.cm/min) than other formulation containing PEG6000. This study concluded the potential use of mucoadhesive in situ nasal gel in terms of ease of administration, accuracy of dosing, prolonged nasal residence and improved nasal bioavailability.
format	Articulo Articulo
author	Dias, Remeth J. Mali, Kailas K. Shinde, Jitendra V. Havaldar, Vijay D. Mali, Rahul K.
author_facet	Dias, Remeth J. Mali, Kailas K. Shinde, Jitendra V. Havaldar, Vijay D. Mali, Rahul K.
author_sort	Dias, Remeth J.
title	Formulation and evaluation of thermoreversible mucoadhesive nasal gels of metoclopramide hydrochloride
title_short	Formulation and evaluation of thermoreversible mucoadhesive nasal gels of metoclopramide hydrochloride
title_full	Formulation and evaluation of thermoreversible mucoadhesive nasal gels of metoclopramide hydrochloride
title_fullStr	Formulation and evaluation of thermoreversible mucoadhesive nasal gels of metoclopramide hydrochloride
title_full_unstemmed	Formulation and evaluation of thermoreversible mucoadhesive nasal gels of metoclopramide hydrochloride
title_sort	formulation and evaluation of thermoreversible mucoadhesive nasal gels of metoclopramide hydrochloride
publishDate	2010
url	http://sedici.unlp.edu.ar/handle/10915/7918 http://www.latamjpharm.org/resumenes/29/3/LAJOP_29_3_1_5.pdf
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bdutipo_str	Repositorios
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Formulation and evaluation of thermoreversible mucoadhesive nasal gels of metoclopramide hydrochloride

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