Study of in vitro and in vivo extraction of kavalactones of pharmaceutical form containing ground plant drug (Piper methysticum G. Forster)

An evaluation of the extraction of pharmacological markers (kavalactones) of the plant species Piper methysticum (kava-kava) was conducted. Capsules containing ground kava-kava were submitted to an in vitro method using a controlled dissolution system where the extractive mediums were a solution of...

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Autores principales:	Richardes Costa, Willian, Rossi Sartori, Lucas, Tavares Carvalho, J.
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2010
Materias:	Farmacia ground plant drug; kavalactones; Piper methysticum Farmacología Plantas medicinales
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7908 http://www.latamjpharm.org/resumenes/29/2/LAJOP_29_2_2_5.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-7908
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia ground plant drug; kavalactones; Piper methysticum Farmacología Plantas medicinales
spellingShingle	Farmacia ground plant drug; kavalactones; Piper methysticum Farmacología Plantas medicinales Richardes Costa, Willian Rossi Sartori, Lucas Tavares Carvalho, J. Study of in vitro and in vivo extraction of kavalactones of pharmaceutical form containing ground plant drug (Piper methysticum G. Forster)
topic_facet	Farmacia ground plant drug; kavalactones; Piper methysticum Farmacología Plantas medicinales
description	An evaluation of the extraction of pharmacological markers (kavalactones) of the plant species Piper methysticum (kava-kava) was conducted. Capsules containing ground kava-kava were submitted to an in vitro method using a controlled dissolution system where the extractive mediums were a solution of 0.1M HCl, phosphate buffered solution (pH = 6.8) and distilled water, at 30 and 60 min, and in vivo that was based on the pylorus ligation method in rats. In the in vitro system starting from 6 capsules (3 g) containing the kava-kava powder, the following extractive concentrations of kavalactones were obtained: HCl (30 min.) = 0.93% (27.9 mg), HCl (60 min.) = 1.1% (33 mg), buff. (30 min) = 2.8% (84 mg), buff. (60 min.) = 0.7% (21 mg), water (30 min.) = 0.71% (21.3 mg) and water (60 min.) = 2.6% (78 mg), while in the in vivo method, 1 and 2 h after administration of 500 mg of the kava-kava powder through gavage, the extractive concentrations of total kavalactones were: 1h = 1.31% (6.55 mg) and 2h = 1.41 % (7.05 mg). In the in vitro system a slight difference was observed among the solutions, which were not statistically significant, and the same occurred with the in vivo experiment, although at the time of 2 h after administration it proved more effective in the extraction of kavalactones by the gastric juice, but below the dose recommended for therapeutic use.
format	Articulo Comunicacion
author	Richardes Costa, Willian Rossi Sartori, Lucas Tavares Carvalho, J.
author_facet	Richardes Costa, Willian Rossi Sartori, Lucas Tavares Carvalho, J.
author_sort	Richardes Costa, Willian
title	Study of in vitro and in vivo extraction of kavalactones of pharmaceutical form containing ground plant drug (Piper methysticum G. Forster)
title_short	Study of in vitro and in vivo extraction of kavalactones of pharmaceutical form containing ground plant drug (Piper methysticum G. Forster)
title_full	Study of in vitro and in vivo extraction of kavalactones of pharmaceutical form containing ground plant drug (Piper methysticum G. Forster)
title_fullStr	Study of in vitro and in vivo extraction of kavalactones of pharmaceutical form containing ground plant drug (Piper methysticum G. Forster)
title_full_unstemmed	Study of in vitro and in vivo extraction of kavalactones of pharmaceutical form containing ground plant drug (Piper methysticum G. Forster)
title_sort	study of in vitro and in vivo extraction of kavalactones of pharmaceutical form containing ground plant drug (piper methysticum g. forster)
publishDate	2010
url	http://sedici.unlp.edu.ar/handle/10915/7908 http://www.latamjpharm.org/resumenes/29/2/LAJOP_29_2_2_5.pdf
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bdutipo_str	Repositorios
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Study of in vitro and in vivo extraction of kavalactones of pharmaceutical form containing ground plant drug (Piper methysticum G. Forster)

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