Development and evaluation of acyclovir mucoadhesive tablet using a novel starch based platform
The present study evaluated novel polymer mixtures prepared by spray drying of an aqueous dispersion of moth bean starch with Carbopol 934P and HPMC K4M for to be used as platform for peroral mucoadhesive drug delivery. 32 factorial designs were employed to evaluate influence of different concentr...
Guardado en:
| Autores principales: | , |
|---|---|
| Formato: | Articulo Comunicacion |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7906 http://www.latamjpharm.org/resumenes/29/2/LAJOP_29_2_2_3.pdf |
| Aporte de: |
| id |
I19-R120-10915-7906 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia acyclovir; Carbopol 934P; HPMC K4M; moth bean starch; mucoadhesive tablet Farmacología Evaluación de drogas |
| spellingShingle |
Farmacia acyclovir; Carbopol 934P; HPMC K4M; moth bean starch; mucoadhesive tablet Farmacología Evaluación de drogas Singh, Akhilesh V. Nath, Lila K. Development and evaluation of acyclovir mucoadhesive tablet using a novel starch based platform |
| topic_facet |
Farmacia acyclovir; Carbopol 934P; HPMC K4M; moth bean starch; mucoadhesive tablet Farmacología Evaluación de drogas |
| description |
The present study evaluated novel polymer mixtures prepared by spray drying of an aqueous
dispersion of moth bean starch with Carbopol 934P and HPMC K4M for to be used as platform for peroral
mucoadhesive drug delivery. 32 factorial designs were employed to evaluate influence of different concentrations
of hydrophilic polymers i.e. Carbopol 934P and HPMC K4M with constant concentration of
moth bean starch on the drug release as well as in vitro adhesion time. All the formulations were studied
for physical evaluation i.e. hadness, friability, content uniformity, drug-excipient compatibility as well as
stability study. Two formulations F1 and F4 out of nine containing low amount of synthetic polymer exhibited
desirable in vitro mucoadhesion time >8 h and drug release >90 % in controlled manner. |
| format |
Articulo Comunicacion |
| author |
Singh, Akhilesh V. Nath, Lila K. |
| author_facet |
Singh, Akhilesh V. Nath, Lila K. |
| author_sort |
Singh, Akhilesh V. |
| title |
Development and evaluation of acyclovir mucoadhesive tablet using a novel starch based platform |
| title_short |
Development and evaluation of acyclovir mucoadhesive tablet using a novel starch based platform |
| title_full |
Development and evaluation of acyclovir mucoadhesive tablet using a novel starch based platform |
| title_fullStr |
Development and evaluation of acyclovir mucoadhesive tablet using a novel starch based platform |
| title_full_unstemmed |
Development and evaluation of acyclovir mucoadhesive tablet using a novel starch based platform |
| title_sort |
development and evaluation of acyclovir mucoadhesive tablet using a novel starch based platform |
| publishDate |
2010 |
| url |
http://sedici.unlp.edu.ar/handle/10915/7906 http://www.latamjpharm.org/resumenes/29/2/LAJOP_29_2_2_3.pdf |
| work_keys_str_mv |
AT singhakhileshv developmentandevaluationofacyclovirmucoadhesivetabletusinganovelstarchbasedplatform AT nathlilak developmentandevaluationofacyclovirmucoadhesivetabletusinganovelstarchbasedplatform |
| bdutipo_str |
Repositorios |
| _version_ |
1764820487071858689 |