Hydrophilic and hydrophobic polymer Based naproxen buccal mucoadhesive film: design and in vitro evaluation

The aim of the present study was to develop a sustained release mucoadhesive buccal film of naproxen, which can be used to treat the inflammation in the oral cavity. The mucoadhesive buccal films were prepared by solvent casting method. The prepared films were evaluated for their physicochemical...

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Autores principales: Haque, Tasnuva, Talukder, Mesbah U., Hossan, Md. S.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
buccal mucoadhesive film; ethyl cellulose; HPMC; naproxen; Na-CMC
Farmacología
Tratamiento médico
Enfermedades de la boca
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7899
http://www.latamjpharm.org/resumenes/29/2/LAJOP_29_2_1_11.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7899
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
buccal mucoadhesive film; ethyl cellulose; HPMC; naproxen; Na-CMC
Farmacología
Tratamiento médico
Enfermedades de la boca
spellingShingle Farmacia
buccal mucoadhesive film; ethyl cellulose; HPMC; naproxen; Na-CMC
Farmacología
Tratamiento médico
Enfermedades de la boca
Haque, Tasnuva
Talukder, Mesbah U.
Hossan, Md. S.
Hydrophilic and hydrophobic polymer Based naproxen buccal mucoadhesive film: design and in vitro evaluation
topic_facet Farmacia
buccal mucoadhesive film; ethyl cellulose; HPMC; naproxen; Na-CMC
Farmacología
Tratamiento médico
Enfermedades de la boca
description The aim of the present study was to develop a sustained release mucoadhesive buccal film of naproxen, which can be used to treat the inflammation in the oral cavity. The mucoadhesive buccal films were prepared by solvent casting method. The prepared films were evaluated for their physicochemical parameters and in vitro release pattern. All the formulations showed uniform weight, thickness, content uniformity and folding endurance. Surface pH was found to be compatible with salivary pH. Na-CMC and HPMC based films (F-3 and F-1) showed highest water uptake (80 and 72% at 4 h) and weight loss (33.40 and 38.48%) as well as ex vivo residence time (270 and 230 min, respectively). Mucoadhesive strength was found to be decreased with the incorporation of hydrophilic polymers. Highest sustained release up to 4 h was found for F-3 (43.56%, MDT 3.941 h) and then for F-1 (69.26%, MDT 3.342 h).
format Articulo
Articulo
author Haque, Tasnuva
Talukder, Mesbah U.
Hossan, Md. S.
author_facet Haque, Tasnuva
Talukder, Mesbah U.
Hossan, Md. S.
author_sort Haque, Tasnuva
title Hydrophilic and hydrophobic polymer Based naproxen buccal mucoadhesive film: design and in vitro evaluation
title_short Hydrophilic and hydrophobic polymer Based naproxen buccal mucoadhesive film: design and in vitro evaluation
title_full Hydrophilic and hydrophobic polymer Based naproxen buccal mucoadhesive film: design and in vitro evaluation
title_fullStr Hydrophilic and hydrophobic polymer Based naproxen buccal mucoadhesive film: design and in vitro evaluation
title_full_unstemmed Hydrophilic and hydrophobic polymer Based naproxen buccal mucoadhesive film: design and in vitro evaluation
title_sort hydrophilic and hydrophobic polymer based naproxen buccal mucoadhesive film: design and in vitro evaluation
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/7899
http://www.latamjpharm.org/resumenes/29/2/LAJOP_29_2_1_11.pdf
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AT talukdermesbahu hydrophilicandhydrophobicpolymerbasednaproxenbuccalmucoadhesivefilmdesignandinvitroevaluation
AT hossanmds hydrophilicandhydrophobicpolymerbasednaproxenbuccalmucoadhesivefilmdesignandinvitroevaluation
bdutipo_str Repositorios
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